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Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection

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Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection. / Lange, Ulrike C; Bialek, Julia K; Walther, Thomas; Hauber, Joachim.

In: VIRUS RES, Vol. 249, 02.04.2018, p. 69-75.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lange, UC, Bialek, JK, Walther, T & Hauber, J 2018, 'Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection', VIRUS RES, vol. 249, pp. 69-75. https://doi.org/10.1016/j.virusres.2018.03.007

APA

Lange, U. C., Bialek, J. K., Walther, T., & Hauber, J. (2018). Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection. VIRUS RES, 249, 69-75. https://doi.org/10.1016/j.virusres.2018.03.007

Vancouver

Lange UC, Bialek JK, Walther T, Hauber J. Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection. VIRUS RES. 2018 Apr 2;249:69-75. https://doi.org/10.1016/j.virusres.2018.03.007

Bibtex

@article{48588f606cb241a483a05f88192195ec,
title = "Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection",
abstract = "HIV infection is characterized by accumulation of proviral sequences within the human host genome. Integration of viral-derived DNA occurs at preferential loci, suggesting a site-specific crosstalk between viral sequences and human genes. We here describe a genome engineering workflow to generate models for HIV-1 infection that for the first time recapitulate proviral integration at selected genomic loci and provide unique tools to study effects of HIV proviral integration site choice. Using this workflow, we have derived two BACH2-HIV-1 reporter models that mimic largely latent integration in the clinically relevant BACH2 gene locus, which has been associated with recurrent integration and HIV-reservoir maintenance in chronically infected patients.",
keywords = "Journal Article",
author = "Lange, {Ulrike C} and Bialek, {Julia K} and Thomas Walther and Joachim Hauber",
note = "Copyright {\textcopyright} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
month = apr,
day = "2",
doi = "10.1016/j.virusres.2018.03.007",
language = "English",
volume = "249",
pages = "69--75",
journal = "VIRUS RES",
issn = "0168-1702",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Pinpointing recurrent proviral integration sites in new models for latent HIV-1 infection

AU - Lange, Ulrike C

AU - Bialek, Julia K

AU - Walther, Thomas

AU - Hauber, Joachim

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018/4/2

Y1 - 2018/4/2

N2 - HIV infection is characterized by accumulation of proviral sequences within the human host genome. Integration of viral-derived DNA occurs at preferential loci, suggesting a site-specific crosstalk between viral sequences and human genes. We here describe a genome engineering workflow to generate models for HIV-1 infection that for the first time recapitulate proviral integration at selected genomic loci and provide unique tools to study effects of HIV proviral integration site choice. Using this workflow, we have derived two BACH2-HIV-1 reporter models that mimic largely latent integration in the clinically relevant BACH2 gene locus, which has been associated with recurrent integration and HIV-reservoir maintenance in chronically infected patients.

AB - HIV infection is characterized by accumulation of proviral sequences within the human host genome. Integration of viral-derived DNA occurs at preferential loci, suggesting a site-specific crosstalk between viral sequences and human genes. We here describe a genome engineering workflow to generate models for HIV-1 infection that for the first time recapitulate proviral integration at selected genomic loci and provide unique tools to study effects of HIV proviral integration site choice. Using this workflow, we have derived two BACH2-HIV-1 reporter models that mimic largely latent integration in the clinically relevant BACH2 gene locus, which has been associated with recurrent integration and HIV-reservoir maintenance in chronically infected patients.

KW - Journal Article

U2 - 10.1016/j.virusres.2018.03.007

DO - 10.1016/j.virusres.2018.03.007

M3 - SCORING: Journal article

C2 - 29550509

VL - 249

SP - 69

EP - 75

JO - VIRUS RES

JF - VIRUS RES

SN - 0168-1702

ER -