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Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy

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Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy. / Sabranski, Michael; Erdbeer, Gesa; Sonntag, Ina; Stoehr, Albrecht; Horst, Heinz-August; Plettenberg, Andreas; Lebherz, Lisa; Stellbrink, Hans-Jürgen; Hoffmann, Christian.

In: AIDS CARE, Vol. 33, No. 4, 04.2021, p. 453-461.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sabranski, M, Erdbeer, G, Sonntag, I, Stoehr, A, Horst, H-A, Plettenberg, A, Lebherz, L, Stellbrink, H-J & Hoffmann, C 2021, 'Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy', AIDS CARE, vol. 33, no. 4, pp. 453-461. https://doi.org/10.1080/09540121.2020.1733466

APA

Sabranski, M., Erdbeer, G., Sonntag, I., Stoehr, A., Horst, H-A., Plettenberg, A., Lebherz, L., Stellbrink, H-J., & Hoffmann, C. (2021). Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy. AIDS CARE, 33(4), 453-461. https://doi.org/10.1080/09540121.2020.1733466

Vancouver

Sabranski M, Erdbeer G, Sonntag I, Stoehr A, Horst H-A, Plettenberg A et al. Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy. AIDS CARE. 2021 Apr;33(4):453-461. https://doi.org/10.1080/09540121.2020.1733466

Bibtex

@article{ed970115962f4e42a8a8d204f6d3e600,
title = "Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy",
abstract = "In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care.",
keywords = "Adult, Aged, Antiretroviral Therapy, Highly Active, Cross-Sectional Studies, Germany/epidemiology, HIV Infections/drug therapy, Health Surveys, Humans, Mental Health, Quality of Life/psychology, Time Factors, Viral Load/drug effects",
author = "Michael Sabranski and Gesa Erdbeer and Ina Sonntag and Albrecht Stoehr and Heinz-August Horst and Andreas Plettenberg and Lisa Lebherz and Hans-J{\"u}rgen Stellbrink and Christian Hoffmann",
year = "2021",
month = apr,
doi = "10.1080/09540121.2020.1733466",
language = "English",
volume = "33",
pages = "453--461",
journal = "AIDS CARE",
issn = "0954-0121",
publisher = "Routledge",
number = "4",

}

RIS

TY - JOUR

T1 - Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy

AU - Sabranski, Michael

AU - Erdbeer, Gesa

AU - Sonntag, Ina

AU - Stoehr, Albrecht

AU - Horst, Heinz-August

AU - Plettenberg, Andreas

AU - Lebherz, Lisa

AU - Stellbrink, Hans-Jürgen

AU - Hoffmann, Christian

PY - 2021/4

Y1 - 2021/4

N2 - In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care.

AB - In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care.

KW - Adult

KW - Aged

KW - Antiretroviral Therapy, Highly Active

KW - Cross-Sectional Studies

KW - Germany/epidemiology

KW - HIV Infections/drug therapy

KW - Health Surveys

KW - Humans

KW - Mental Health

KW - Quality of Life/psychology

KW - Time Factors

KW - Viral Load/drug effects

U2 - 10.1080/09540121.2020.1733466

DO - 10.1080/09540121.2020.1733466

M3 - SCORING: Journal article

C2 - 32106695

VL - 33

SP - 453

EP - 461

JO - AIDS CARE

JF - AIDS CARE

SN - 0954-0121

IS - 4

ER -