Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy
Standard
Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy. / Sabranski, Michael; Erdbeer, Gesa; Sonntag, Ina; Stoehr, Albrecht; Horst, Heinz-August; Plettenberg, Andreas; Lebherz, Lisa; Stellbrink, Hans-Jürgen; Hoffmann, Christian.
in: AIDS CARE, Jahrgang 33, Nr. 4, 04.2021, S. 453-461.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy
AU - Sabranski, Michael
AU - Erdbeer, Gesa
AU - Sonntag, Ina
AU - Stoehr, Albrecht
AU - Horst, Heinz-August
AU - Plettenberg, Andreas
AU - Lebherz, Lisa
AU - Stellbrink, Hans-Jürgen
AU - Hoffmann, Christian
PY - 2021/4
Y1 - 2021/4
N2 - In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care.
AB - In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care.
KW - Adult
KW - Aged
KW - Antiretroviral Therapy, Highly Active
KW - Cross-Sectional Studies
KW - Germany/epidemiology
KW - HIV Infections/drug therapy
KW - Health Surveys
KW - Humans
KW - Mental Health
KW - Quality of Life/psychology
KW - Time Factors
KW - Viral Load/drug effects
U2 - 10.1080/09540121.2020.1733466
DO - 10.1080/09540121.2020.1733466
M3 - SCORING: Journal article
C2 - 32106695
VL - 33
SP - 453
EP - 461
JO - AIDS CARE
JF - AIDS CARE
SN - 0954-0121
IS - 4
ER -