Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue
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Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue. / Burhan, Sazgar; Detrez, Nicolas; Rewerts, Katharina; Strenge, Paul; Buschschlüter, Steffen; Kren, Jessica; Hagel, Christian; Bonsanto, Matteo Mario; Brinkmann, Ralf; Huber, Robert.
In: BIOMED OPT EXPRESS, Vol. 15, No. 2, 01.02.2024, p. 1038-1058.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue
AU - Burhan, Sazgar
AU - Detrez, Nicolas
AU - Rewerts, Katharina
AU - Strenge, Paul
AU - Buschschlüter, Steffen
AU - Kren, Jessica
AU - Hagel, Christian
AU - Bonsanto, Matteo Mario
AU - Brinkmann, Ralf
AU - Huber, Robert
N1 - © 2024 Optica Publishing Group.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm's reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm's dependability.
AB - During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm's reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm's dependability.
U2 - 10.1364/BOE.510020
DO - 10.1364/BOE.510020
M3 - SCORING: Journal article
C2 - 38404346
VL - 15
SP - 1038
EP - 1058
JO - BIOMED OPT EXPRESS
JF - BIOMED OPT EXPRESS
SN - 2156-7085
IS - 2
ER -