Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue

Sazgar Burhan; Nicolas Detrez; Katharina Rewerts; Paul Strenge; Steffen Buschschlüter; Jessica Kren; Christian Hagel; Matteo Mario Bonsanto; Ralf Brinkmann; Robert Huber

doi:10.1364/BOE.510020

Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue

Standard

Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue. / Burhan, Sazgar; Detrez, Nicolas; Rewerts, Katharina; Strenge, Paul; Buschschlüter, Steffen; Kren, Jessica; Hagel, Christian; Bonsanto, Matteo Mario; Brinkmann, Ralf; Huber, Robert.

in: BIOMED OPT EXPRESS, Jahrgang 15, Nr. 2, 01.02.2024, S. 1038-1058.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Burhan, S, Detrez, N, Rewerts, K, Strenge, P, Buschschlüter, S, Kren, J, Hagel, C, Bonsanto, MM, Brinkmann, R & Huber, R 2024, 'Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue', BIOMED OPT EXPRESS, Jg. 15, Nr. 2, S. 1038-1058. https://doi.org/10.1364/BOE.510020

APA

Burhan, S., Detrez, N., Rewerts, K., Strenge, P., Buschschlüter, S., Kren, J., Hagel, C., Bonsanto, M. M., Brinkmann, R., & Huber, R. (2024). Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue. BIOMED OPT EXPRESS, 15(2), 1038-1058. https://doi.org/10.1364/BOE.510020

Vancouver

Burhan S, Detrez N, Rewerts K, Strenge P, Buschschlüter S, Kren J et al. Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue. BIOMED OPT EXPRESS. 2024 Feb 1;15(2):1038-1058. https://doi.org/10.1364/BOE.510020

Bibtex

@article{6e3ad6258c8c4d09bf6685a3315f7566,

title = "Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue",

abstract = "During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm's reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm's dependability.",

author = "Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Paul Strenge and Steffen Buschschl{\"u}ter and Jessica Kren and Christian Hagel and Bonsanto, {Matteo Mario} and Ralf Brinkmann and Robert Huber",

note = "{\textcopyright} 2024 Optica Publishing Group.",

year = "2024",

month = feb,

day = "1",

doi = "10.1364/BOE.510020",

language = "English",

volume = "15",

pages = "1038--1058",

journal = "BIOMED OPT EXPRESS",

issn = "2156-7085",

publisher = "The Optical Society",

number = "2",

}

RIS

TY - JOUR

T1 - Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue

AU - Burhan, Sazgar

AU - Detrez, Nicolas

AU - Rewerts, Katharina

AU - Strenge, Paul

AU - Buschschlüter, Steffen

AU - Kren, Jessica

AU - Hagel, Christian

AU - Bonsanto, Matteo Mario

AU - Brinkmann, Ralf

AU - Huber, Robert

PY - 2024/2/1

Y1 - 2024/2/1

N2 - During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm's reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm's dependability.

AB - During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm's reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm's dependability.

U2 - 10.1364/BOE.510020

DO - 10.1364/BOE.510020

M3 - SCORING: Journal article

C2 - 38404346

VL - 15

SP - 1038

EP - 1058

JO - BIOMED OPT EXPRESS

JF - BIOMED OPT EXPRESS

SN - 2156-7085

IS - 2

ER -