Persistent activity in human parietal cortex mediates perceptual choice repetition bias
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Persistent activity in human parietal cortex mediates perceptual choice repetition bias. / Urai, Anne E; Donner, Tobias H.
In: NAT COMMUN, Vol. 13, No. 1, 6015, 12.10.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Persistent activity in human parietal cortex mediates perceptual choice repetition bias
AU - Urai, Anne E
AU - Donner, Tobias H
N1 - © 2022. The Author(s).
PY - 2022/10/12
Y1 - 2022/10/12
N2 - Humans and other animals tend to repeat or alternate their previous choices, even when judging sensory stimuli presented in a random sequence. It is unclear if and how sensory, associative, and motor cortical circuits produce these idiosyncratic behavioral biases. Here, we combined behavioral modeling of a visual perceptual decision with magnetoencephalographic (MEG) analyses of neural dynamics, across multiple regions of the human cerebral cortex. We identified distinct history-dependent neural signals in motor and posterior parietal cortex. Gamma-band activity in parietal cortex tracked previous choices in a sustained fashion, and biased evidence accumulation toward choice repetition; sustained beta-band activity in motor cortex inversely reflected the previous motor action, and biased the accumulation starting point toward alternation. The parietal, not motor, signal mediated the impact of previous on current choice and reflected individual differences in choice repetition. In sum, parietal cortical signals seem to play a key role in shaping choice sequences.
AB - Humans and other animals tend to repeat or alternate their previous choices, even when judging sensory stimuli presented in a random sequence. It is unclear if and how sensory, associative, and motor cortical circuits produce these idiosyncratic behavioral biases. Here, we combined behavioral modeling of a visual perceptual decision with magnetoencephalographic (MEG) analyses of neural dynamics, across multiple regions of the human cerebral cortex. We identified distinct history-dependent neural signals in motor and posterior parietal cortex. Gamma-band activity in parietal cortex tracked previous choices in a sustained fashion, and biased evidence accumulation toward choice repetition; sustained beta-band activity in motor cortex inversely reflected the previous motor action, and biased the accumulation starting point toward alternation. The parietal, not motor, signal mediated the impact of previous on current choice and reflected individual differences in choice repetition. In sum, parietal cortical signals seem to play a key role in shaping choice sequences.
KW - Animals
KW - Choice Behavior
KW - Decision Making
KW - Humans
KW - Magnetoencephalography
KW - Motor Cortex
KW - Parietal Lobe
U2 - 10.1038/s41467-022-33237-5
DO - 10.1038/s41467-022-33237-5
M3 - SCORING: Journal article
C2 - 36224207
VL - 13
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
M1 - 6015
ER -