Persistence of Aβ seeds in APP null mouse brain
Standard
Persistence of Aβ seeds in APP null mouse brain. / Ye, Lan; Fritschi, Sarah K; Schelle, Juliane; Obermüller, Ulrike; Degenhardt, Karoline; Kaeser, Stephan A; Eisele, Yvonne S; Walker, Lary C; Baumann, Frank; Staufenbiel, Matthias; Jucker, Mathias.
In: NAT NEUROSCI, Vol. 18, No. 11, 11.2015, p. 1559-61.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Persistence of Aβ seeds in APP null mouse brain
AU - Ye, Lan
AU - Fritschi, Sarah K
AU - Schelle, Juliane
AU - Obermüller, Ulrike
AU - Degenhardt, Karoline
AU - Kaeser, Stephan A
AU - Eisele, Yvonne S
AU - Walker, Lary C
AU - Baumann, Frank
AU - Staufenbiel, Matthias
AU - Jucker, Mathias
PY - 2015/11
Y1 - 2015/11
N2 - Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.
AB - Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.
KW - Alzheimer Disease/metabolism
KW - Amyloid beta-Protein Precursor/administration & dosage
KW - Amyloidosis/pathology
KW - Animals
KW - Brain/drug effects
KW - Disease Models, Animal
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Mice, Transgenic
KW - Plaque, Amyloid/metabolism
U2 - 10.1038/nn.4117
DO - 10.1038/nn.4117
M3 - SCORING: Journal article
C2 - 26352792
VL - 18
SP - 1559
EP - 1561
JO - NAT NEUROSCI
JF - NAT NEUROSCI
SN - 1097-6256
IS - 11
ER -