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Persistence of Aβ seeds in APP null mouse brain

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Persistence of Aβ seeds in APP null mouse brain. / Ye, Lan; Fritschi, Sarah K; Schelle, Juliane; Obermüller, Ulrike; Degenhardt, Karoline; Kaeser, Stephan A; Eisele, Yvonne S; Walker, Lary C; Baumann, Frank; Staufenbiel, Matthias; Jucker, Mathias.

in: NAT NEUROSCI, Jahrgang 18, Nr. 11, 11.2015, S. 1559-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ye, L, Fritschi, SK, Schelle, J, Obermüller, U, Degenhardt, K, Kaeser, SA, Eisele, YS, Walker, LC, Baumann, F, Staufenbiel, M & Jucker, M 2015, 'Persistence of Aβ seeds in APP null mouse brain', NAT NEUROSCI, Jg. 18, Nr. 11, S. 1559-61. https://doi.org/10.1038/nn.4117

APA

Ye, L., Fritschi, S. K., Schelle, J., Obermüller, U., Degenhardt, K., Kaeser, S. A., Eisele, Y. S., Walker, L. C., Baumann, F., Staufenbiel, M., & Jucker, M. (2015). Persistence of Aβ seeds in APP null mouse brain. NAT NEUROSCI, 18(11), 1559-61. https://doi.org/10.1038/nn.4117

Vancouver

Ye L, Fritschi SK, Schelle J, Obermüller U, Degenhardt K, Kaeser SA et al. Persistence of Aβ seeds in APP null mouse brain. NAT NEUROSCI. 2015 Nov;18(11):1559-61. https://doi.org/10.1038/nn.4117

Bibtex

@article{03ff544d5fe44ab4b3a4eefd31d34d6c,
title = "Persistence of Aβ seeds in APP null mouse brain",
abstract = "Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ. ",
keywords = "Alzheimer Disease/metabolism, Amyloid beta-Protein Precursor/administration & dosage, Amyloidosis/pathology, Animals, Brain/drug effects, Disease Models, Animal, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Plaque, Amyloid/metabolism",
author = "Lan Ye and Fritschi, {Sarah K} and Juliane Schelle and Ulrike Oberm{\"u}ller and Karoline Degenhardt and Kaeser, {Stephan A} and Eisele, {Yvonne S} and Walker, {Lary C} and Frank Baumann and Matthias Staufenbiel and Mathias Jucker",
year = "2015",
month = nov,
doi = "10.1038/nn.4117",
language = "English",
volume = "18",
pages = "1559--61",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Persistence of Aβ seeds in APP null mouse brain

AU - Ye, Lan

AU - Fritschi, Sarah K

AU - Schelle, Juliane

AU - Obermüller, Ulrike

AU - Degenhardt, Karoline

AU - Kaeser, Stephan A

AU - Eisele, Yvonne S

AU - Walker, Lary C

AU - Baumann, Frank

AU - Staufenbiel, Matthias

AU - Jucker, Mathias

PY - 2015/11

Y1 - 2015/11

N2 - Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.

AB - Cerebral β-amyloidosis is induced by inoculation of Aβ seeds into APP transgenic mice, but not into App(-/-) (APP null) mice. We found that brain extracts from APP null mice that had been inoculated with Aβ seeds up to 6 months previously still induced β-amyloidosis in APP transgenic hosts following secondary transmission. Thus, Aβ seeds can persist in the brain for months, and they regain propagative and pathogenic activity in the presence of host Aβ.

KW - Alzheimer Disease/metabolism

KW - Amyloid beta-Protein Precursor/administration & dosage

KW - Amyloidosis/pathology

KW - Animals

KW - Brain/drug effects

KW - Disease Models, Animal

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mice, Transgenic

KW - Plaque, Amyloid/metabolism

U2 - 10.1038/nn.4117

DO - 10.1038/nn.4117

M3 - SCORING: Journal article

C2 - 26352792

VL - 18

SP - 1559

EP - 1561

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 11

ER -