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Penetration of moxifloxacin into rat mandibular bone and soft tissue.

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Penetration of moxifloxacin into rat mandibular bone and soft tissue. / Cachovan, Georg; Nergiz, Ibrahim; Thuss, Uwe; Siefert, Hans-Martin; Sobottka, Ingo; Oral, Okhan; Platzer, Ursula; Dogan-Onur, Ozen.

In: ACTA ODONTOL SCAND, Vol. 67, No. 3, 3, 2009, p. 182-186.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cachovan, G, Nergiz, I, Thuss, U, Siefert, H-M, Sobottka, I, Oral, O, Platzer, U & Dogan-Onur, O 2009, 'Penetration of moxifloxacin into rat mandibular bone and soft tissue.', ACTA ODONTOL SCAND, vol. 67, no. 3, 3, pp. 182-186. <http://www.ncbi.nlm.nih.gov/pubmed/19306136?dopt=Citation>

APA

Cachovan, G., Nergiz, I., Thuss, U., Siefert, H-M., Sobottka, I., Oral, O., Platzer, U., & Dogan-Onur, O. (2009). Penetration of moxifloxacin into rat mandibular bone and soft tissue. ACTA ODONTOL SCAND, 67(3), 182-186. [3]. http://www.ncbi.nlm.nih.gov/pubmed/19306136?dopt=Citation

Vancouver

Cachovan G, Nergiz I, Thuss U, Siefert H-M, Sobottka I, Oral O et al. Penetration of moxifloxacin into rat mandibular bone and soft tissue. ACTA ODONTOL SCAND. 2009;67(3):182-186. 3.

Bibtex

@article{d68b1a89809344e2b55ce989ba1bf279,
title = "Penetration of moxifloxacin into rat mandibular bone and soft tissue.",
abstract = "OBJECTIVE: Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. MATERIAL AND METHODS: Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis. RESULTS: The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. CONCLUSIONS: Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.",
author = "Georg Cachovan and Ibrahim Nergiz and Uwe Thuss and Hans-Martin Siefert and Ingo Sobottka and Okhan Oral and Ursula Platzer and Ozen Dogan-Onur",
year = "2009",
language = "Deutsch",
volume = "67",
pages = "182--186",
journal = "ACTA ODONTOL SCAND",
issn = "0001-6357",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Penetration of moxifloxacin into rat mandibular bone and soft tissue.

AU - Cachovan, Georg

AU - Nergiz, Ibrahim

AU - Thuss, Uwe

AU - Siefert, Hans-Martin

AU - Sobottka, Ingo

AU - Oral, Okhan

AU - Platzer, Ursula

AU - Dogan-Onur, Ozen

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. MATERIAL AND METHODS: Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis. RESULTS: The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. CONCLUSIONS: Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.

AB - OBJECTIVE: Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. MATERIAL AND METHODS: Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis. RESULTS: The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. CONCLUSIONS: Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.

M3 - SCORING: Zeitschriftenaufsatz

VL - 67

SP - 182

EP - 186

JO - ACTA ODONTOL SCAND

JF - ACTA ODONTOL SCAND

SN - 0001-6357

IS - 3

M1 - 3

ER -