Penetration of moxifloxacin into rat mandibular bone and soft tissue.
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Penetration of moxifloxacin into rat mandibular bone and soft tissue. / Cachovan, Georg; Nergiz, Ibrahim; Thuss, Uwe; Siefert, Hans-Martin; Sobottka, Ingo; Oral, Okhan; Platzer, Ursula; Dogan-Onur, Ozen.
in: ACTA ODONTOL SCAND, Jahrgang 67, Nr. 3, 3, 2009, S. 182-186.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Penetration of moxifloxacin into rat mandibular bone and soft tissue.
AU - Cachovan, Georg
AU - Nergiz, Ibrahim
AU - Thuss, Uwe
AU - Siefert, Hans-Martin
AU - Sobottka, Ingo
AU - Oral, Okhan
AU - Platzer, Ursula
AU - Dogan-Onur, Ozen
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. MATERIAL AND METHODS: Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis. RESULTS: The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. CONCLUSIONS: Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.
AB - OBJECTIVE: Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. MATERIAL AND METHODS: Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis. RESULTS: The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. CONCLUSIONS: Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.
M3 - SCORING: Zeitschriftenaufsatz
VL - 67
SP - 182
EP - 186
JO - ACTA ODONTOL SCAND
JF - ACTA ODONTOL SCAND
SN - 0001-6357
IS - 3
M1 - 3
ER -