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Peer victimization and its impact on adolescent brain development and psychopathology

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Peer victimization and its impact on adolescent brain development and psychopathology. / Quinlan, Erin Burke; Barker, Edward D; Luo, Qiang; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Chaarani, Bader; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Smolka, Michael N; Fröhner, Juliane H; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium.

In: MOL PSYCHIATR, Vol. 25, 11.2020, p. 3066–3076.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Quinlan, EB, Barker, ED, Luo, Q, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Desrivières, S, Flor, H, Frouin, V, Garavan, H, Chaarani, B, Gowland, P, Heinz, A, Brühl, R, Martinot, J-L, Martinot, M-LP, Nees, F, Orfanos, DP, Paus, T, Poustka, L, Hohmann, S, Smolka, MN, Fröhner, JH, Walter, H, Whelan, R, Schumann, G & IMAGEN Consortium 2020, 'Peer victimization and its impact on adolescent brain development and psychopathology', MOL PSYCHIATR, vol. 25, pp. 3066–3076. https://doi.org/10.1038/s41380-018-0297-9

APA

Quinlan, E. B., Barker, E. D., Luo, Q., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Chaarani, B., Gowland, P., Heinz, A., Brühl, R., Martinot, J-L., Martinot, M-L. P., Nees, F., Orfanos, D. P., ... IMAGEN Consortium (2020). Peer victimization and its impact on adolescent brain development and psychopathology. MOL PSYCHIATR, 25, 3066–3076. https://doi.org/10.1038/s41380-018-0297-9

Vancouver

Quinlan EB, Barker ED, Luo Q, Banaschewski T, Bokde ALW, Bromberg U et al. Peer victimization and its impact on adolescent brain development and psychopathology. MOL PSYCHIATR. 2020 Nov;25:3066–3076. https://doi.org/10.1038/s41380-018-0297-9

Bibtex

@article{5f0f296371a6480a9e6c049f80d1570f,
title = "Peer victimization and its impact on adolescent brain development and psychopathology",
abstract = "Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = -2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004-0.109). This was also true for the left caudate (95% CI = 0.002-0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.",
author = "Quinlan, {Erin Burke} and Barker, {Edward D} and Qiang Luo and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Hugh Garavan and Bader Chaarani and Penny Gowland and Andreas Heinz and R{\"u}diger Br{\"u}hl and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Sarah Hohmann and Smolka, {Michael N} and Fr{\"o}hner, {Juliane H} and Henrik Walter and Robert Whelan and Gunter Schumann and {IMAGEN Consortium}",
year = "2020",
month = nov,
doi = "10.1038/s41380-018-0297-9",
language = "English",
volume = "25",
pages = "3066–3076",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Peer victimization and its impact on adolescent brain development and psychopathology

AU - Quinlan, Erin Burke

AU - Barker, Edward D

AU - Luo, Qiang

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Chaarani, Bader

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Brühl, Rüdiger

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Smolka, Michael N

AU - Fröhner, Juliane H

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - IMAGEN Consortium

PY - 2020/11

Y1 - 2020/11

N2 - Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = -2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004-0.109). This was also true for the left caudate (95% CI = 0.002-0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.

AB - Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = -2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004-0.109). This was also true for the left caudate (95% CI = 0.002-0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.

U2 - 10.1038/s41380-018-0297-9

DO - 10.1038/s41380-018-0297-9

M3 - SCORING: Journal article

C2 - 30542059

VL - 25

SP - 3066

EP - 3076

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

ER -