Peer victimization and its impact on adolescent brain development and psychopathology
Standard
Peer victimization and its impact on adolescent brain development and psychopathology. / Quinlan, Erin Burke; Barker, Edward D; Luo, Qiang; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Chaarani, Bader; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Hohmann, Sarah; Smolka, Michael N; Fröhner, Juliane H; Walter, Henrik; Whelan, Robert; Schumann, Gunter; IMAGEN Consortium.
in: MOL PSYCHIATR, Jahrgang 25, 11.2020, S. 3066–3076.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Peer victimization and its impact on adolescent brain development and psychopathology
AU - Quinlan, Erin Burke
AU - Barker, Edward D
AU - Luo, Qiang
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Garavan, Hugh
AU - Chaarani, Bader
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Brühl, Rüdiger
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Hohmann, Sarah
AU - Smolka, Michael N
AU - Fröhner, Juliane H
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - IMAGEN Consortium
PY - 2020/11
Y1 - 2020/11
N2 - Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = -2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004-0.109). This was also true for the left caudate (95% CI = 0.002-0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.
AB - Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Latent profile analysis identified groups of adolescents with different experiential patterns of victimization. We then associated the victimization trajectories and brain volume changes with depression, generalized anxiety, and hyperactivity symptoms at age 19. Repeated measures ANOVA revealed time-by-victimization interactions on left putamen volume (F = 4.38, p = 0.037). Changes in left putamen volume were negatively associated with generalized anxiety (t = -2.32, p = 0.020). Notably, peer victimization was indirectly associated with generalized anxiety via decreases in putamen volume (95% CI = 0.004-0.109). This was also true for the left caudate (95% CI = 0.002-0.099). These data suggest that the experience of chronic peer victimization during adolescence might induce psychopathology-relevant deviations from normative brain development. Early peer victimization interventions could prevent such pathological changes.
U2 - 10.1038/s41380-018-0297-9
DO - 10.1038/s41380-018-0297-9
M3 - SCORING: Journal article
C2 - 30542059
VL - 25
SP - 3066
EP - 3076
JO - MOL PSYCHIATR
JF - MOL PSYCHIATR
SN - 1359-4184
ER -