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Pathophysiology in Microvillus inclusion disease

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Pathophysiology in Microvillus inclusion disease. / Reinshagen, K; Naim, H; Heusipp, G; Zimmer, K-P.

In: Z GASTROENTEROL, Vol. 44, No. 8, 08.2006, p. 667-71.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Reinshagen, K, Naim, H, Heusipp, G & Zimmer, K-P 2006, 'Pathophysiology in Microvillus inclusion disease', Z GASTROENTEROL, vol. 44, no. 8, pp. 667-71. https://doi.org/10.1055/s-2006-926903

APA

Reinshagen, K., Naim, H., Heusipp, G., & Zimmer, K-P. (2006). Pathophysiology in Microvillus inclusion disease. Z GASTROENTEROL, 44(8), 667-71. https://doi.org/10.1055/s-2006-926903

Vancouver

Reinshagen K, Naim H, Heusipp G, Zimmer K-P. Pathophysiology in Microvillus inclusion disease. Z GASTROENTEROL. 2006 Aug;44(8):667-71. https://doi.org/10.1055/s-2006-926903

Bibtex

@article{9db7005779714acf8a79d237fe903c35,
title = "Pathophysiology in Microvillus inclusion disease",
abstract = "Microvillus inclusion disease (MID) is a congenital disorder with the clinical signs of watery diarrhea often beginning in the first days of life. The main pathological features of the disease include a villus atrophy and an accumulation of periodic acid-Schiff (PAS)-positive material within the apical cytoplasm of enterocytes on the light microscopy level. Electron microscopic criteria are pathognomonic consisting of an increased amount of secretory granules preferentially in crypt epithelial cells and of the presence of microvillus inclusion bodies (MIBs) which are most frequently found in villus enterocytes. Until now the basic molecular defects have not been disclosed completely. In this review we discuss the actual pathogenetic hypothesis and the therapeutic options besides small bowel transplantation.",
keywords = "Diarrhea/congenital, Humans, Inclusion Bodies/pathology, Malabsorption Syndromes/pathology, Microvilli/pathology",
author = "K Reinshagen and H Naim and G Heusipp and K-P Zimmer",
year = "2006",
month = aug,
doi = "10.1055/s-2006-926903",
language = "English",
volume = "44",
pages = "667--71",
journal = "Z GASTROENTEROL",
issn = "0044-2771",
publisher = "Karl Demeter Verlag GmbH",
number = "8",

}

RIS

TY - JOUR

T1 - Pathophysiology in Microvillus inclusion disease

AU - Reinshagen, K

AU - Naim, H

AU - Heusipp, G

AU - Zimmer, K-P

PY - 2006/8

Y1 - 2006/8

N2 - Microvillus inclusion disease (MID) is a congenital disorder with the clinical signs of watery diarrhea often beginning in the first days of life. The main pathological features of the disease include a villus atrophy and an accumulation of periodic acid-Schiff (PAS)-positive material within the apical cytoplasm of enterocytes on the light microscopy level. Electron microscopic criteria are pathognomonic consisting of an increased amount of secretory granules preferentially in crypt epithelial cells and of the presence of microvillus inclusion bodies (MIBs) which are most frequently found in villus enterocytes. Until now the basic molecular defects have not been disclosed completely. In this review we discuss the actual pathogenetic hypothesis and the therapeutic options besides small bowel transplantation.

AB - Microvillus inclusion disease (MID) is a congenital disorder with the clinical signs of watery diarrhea often beginning in the first days of life. The main pathological features of the disease include a villus atrophy and an accumulation of periodic acid-Schiff (PAS)-positive material within the apical cytoplasm of enterocytes on the light microscopy level. Electron microscopic criteria are pathognomonic consisting of an increased amount of secretory granules preferentially in crypt epithelial cells and of the presence of microvillus inclusion bodies (MIBs) which are most frequently found in villus enterocytes. Until now the basic molecular defects have not been disclosed completely. In this review we discuss the actual pathogenetic hypothesis and the therapeutic options besides small bowel transplantation.

KW - Diarrhea/congenital

KW - Humans

KW - Inclusion Bodies/pathology

KW - Malabsorption Syndromes/pathology

KW - Microvilli/pathology

U2 - 10.1055/s-2006-926903

DO - 10.1055/s-2006-926903

M3 - SCORING: Review article

C2 - 16902898

VL - 44

SP - 667

EP - 671

JO - Z GASTROENTEROL

JF - Z GASTROENTEROL

SN - 0044-2771

IS - 8

ER -