Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study
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Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study. / Krumkamp, Ralf; Kohsar, Matin; Nolte, Kolja; Hogan, Benedikt; Eibach, Daniel; Jaeger, Anna; Akenten, Charity Wiafe; Drosten, Christian; Boahen, Kennedy Gyau; Sarpong, Nimako; Eckerle, Isabella; Binger, Tabea; Owusu-Dabo, Ellis; May, Jürgen; Kreuels, Benno.
In: SCI REP-UK, Vol. 13, No. 1, 2443, 10.02.2023.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study
AU - Krumkamp, Ralf
AU - Kohsar, Matin
AU - Nolte, Kolja
AU - Hogan, Benedikt
AU - Eibach, Daniel
AU - Jaeger, Anna
AU - Akenten, Charity Wiafe
AU - Drosten, Christian
AU - Boahen, Kennedy Gyau
AU - Sarpong, Nimako
AU - Eckerle, Isabella
AU - Binger, Tabea
AU - Owusu-Dabo, Ellis
AU - May, Jürgen
AU - Kreuels, Benno
N1 - © 2023. The Author(s).
PY - 2023/2/10
Y1 - 2023/2/10
N2 - Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0-1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2-758.6), H. influenzae (aOR 4.1; 95% CI 2.2-7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7-3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26-42), H. influenzae (10%; 95% CI 2-19) and influenza (10%; 95% CI 2-18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.
AB - Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0-1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2-758.6), H. influenzae (aOR 4.1; 95% CI 2.2-7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7-3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26-42), H. influenzae (10%; 95% CI 2-19) and influenza (10%; 95% CI 2-18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.
KW - Humans
KW - Child
KW - Infant
KW - Child, Preschool
KW - Ghana/epidemiology
KW - Influenza, Human/epidemiology
KW - Case-Control Studies
KW - COVID-19
KW - SARS-CoV-2
KW - Respiratory Tract Infections/epidemiology
KW - Respiratory Syncytial Virus, Human
KW - Streptococcus pneumoniae
KW - Haemophilus influenzae
KW - Hospitalization
KW - Respiratory Syncytial Virus Infections/epidemiology
U2 - 10.1038/s41598-023-29410-5
DO - 10.1038/s41598-023-29410-5
M3 - SCORING: Journal article
C2 - 36765075
VL - 13
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
M1 - 2443
ER -