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Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study

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Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study. / Krumkamp, Ralf; Kohsar, Matin; Nolte, Kolja; Hogan, Benedikt; Eibach, Daniel; Jaeger, Anna; Akenten, Charity Wiafe; Drosten, Christian; Boahen, Kennedy Gyau; Sarpong, Nimako; Eckerle, Isabella; Binger, Tabea; Owusu-Dabo, Ellis; May, Jürgen; Kreuels, Benno.

in: SCI REP-UK, Jahrgang 13, Nr. 1, 2443, 10.02.2023.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Krumkamp, R, Kohsar, M, Nolte, K, Hogan, B, Eibach, D, Jaeger, A, Akenten, CW, Drosten, C, Boahen, KG, Sarpong, N, Eckerle, I, Binger, T, Owusu-Dabo, E, May, J & Kreuels, B 2023, 'Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study', SCI REP-UK, Jg. 13, Nr. 1, 2443. https://doi.org/10.1038/s41598-023-29410-5

APA

Krumkamp, R., Kohsar, M., Nolte, K., Hogan, B., Eibach, D., Jaeger, A., Akenten, C. W., Drosten, C., Boahen, K. G., Sarpong, N., Eckerle, I., Binger, T., Owusu-Dabo, E., May, J., & Kreuels, B. (2023). Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study. SCI REP-UK, 13(1), [2443]. https://doi.org/10.1038/s41598-023-29410-5

Vancouver

Krumkamp R, Kohsar M, Nolte K, Hogan B, Eibach D, Jaeger A et al. Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study. SCI REP-UK. 2023 Feb 10;13(1). 2443. https://doi.org/10.1038/s41598-023-29410-5

Bibtex

@article{30fa02d02bdd419e8b34d00e7ce122c4,
title = "Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study",
abstract = "Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0-1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2-758.6), H. influenzae (aOR 4.1; 95% CI 2.2-7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7-3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26-42), H. influenzae (10%; 95% CI 2-19) and influenza (10%; 95% CI 2-18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.",
keywords = "Humans, Child, Infant, Child, Preschool, Ghana/epidemiology, Influenza, Human/epidemiology, Case-Control Studies, COVID-19, SARS-CoV-2, Respiratory Tract Infections/epidemiology, Respiratory Syncytial Virus, Human, Streptococcus pneumoniae, Haemophilus influenzae, Hospitalization, Respiratory Syncytial Virus Infections/epidemiology",
author = "Ralf Krumkamp and Matin Kohsar and Kolja Nolte and Benedikt Hogan and Daniel Eibach and Anna Jaeger and Akenten, {Charity Wiafe} and Christian Drosten and Boahen, {Kennedy Gyau} and Nimako Sarpong and Isabella Eckerle and Tabea Binger and Ellis Owusu-Dabo and J{\"u}rgen May and Benno Kreuels",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = feb,
day = "10",
doi = "10.1038/s41598-023-29410-5",
language = "English",
volume = "13",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study

AU - Krumkamp, Ralf

AU - Kohsar, Matin

AU - Nolte, Kolja

AU - Hogan, Benedikt

AU - Eibach, Daniel

AU - Jaeger, Anna

AU - Akenten, Charity Wiafe

AU - Drosten, Christian

AU - Boahen, Kennedy Gyau

AU - Sarpong, Nimako

AU - Eckerle, Isabella

AU - Binger, Tabea

AU - Owusu-Dabo, Ellis

AU - May, Jürgen

AU - Kreuels, Benno

N1 - © 2023. The Author(s).

PY - 2023/2/10

Y1 - 2023/2/10

N2 - Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0-1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2-758.6), H. influenzae (aOR 4.1; 95% CI 2.2-7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7-3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26-42), H. influenzae (10%; 95% CI 2-19) and influenza (10%; 95% CI 2-18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.

AB - Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0-1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2-758.6), H. influenzae (aOR 4.1; 95% CI 2.2-7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7-3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26-42), H. influenzae (10%; 95% CI 2-19) and influenza (10%; 95% CI 2-18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.

KW - Humans

KW - Child

KW - Infant

KW - Child, Preschool

KW - Ghana/epidemiology

KW - Influenza, Human/epidemiology

KW - Case-Control Studies

KW - COVID-19

KW - SARS-CoV-2

KW - Respiratory Tract Infections/epidemiology

KW - Respiratory Syncytial Virus, Human

KW - Streptococcus pneumoniae

KW - Haemophilus influenzae

KW - Hospitalization

KW - Respiratory Syncytial Virus Infections/epidemiology

U2 - 10.1038/s41598-023-29410-5

DO - 10.1038/s41598-023-29410-5

M3 - SCORING: Journal article

C2 - 36765075

VL - 13

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 2443

ER -