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Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.

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Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. / von Leitner, Eike-Christin; Klinke, Anna; Atzler, Dorothee; Slocum, Jessica L; Lund, Natalie; Kielstein, Jan T; Maas, Renke; Schmidt-Haupt, Robin; Pekarova, Michaela; Hellwinkel, Olaf; Tsikas, Dimitrios; D'Alecy, Louis G; Lau, Denise; Willems, Stephan; Kubala, Lukas; Ehmke, Heimo; Meinertz, Thomas; Blankenberg, Stefan; Schwedhelm, Edzard; Gadegbeku, Crystal A; Böger, Rainer; Baldus, Stephan; Sydow, Karsten.

In: CIRCULATION, Vol. 124, No. 24, 24, 2011, p. 2735-2745.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

von Leitner, E-C, Klinke, A, Atzler, D, Slocum, JL, Lund, N, Kielstein, JT, Maas, R, Schmidt-Haupt, R, Pekarova, M, Hellwinkel, O, Tsikas, D, D'Alecy, LG, Lau, D, Willems, S, Kubala, L, Ehmke, H, Meinertz, T, Blankenberg, S, Schwedhelm, E, Gadegbeku, CA, Böger, R, Baldus, S & Sydow, K 2011, 'Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.', CIRCULATION, vol. 124, no. 24, 24, pp. 2735-2745. <http://www.ncbi.nlm.nih.gov/pubmed/22082678?dopt=Citation>

APA

von Leitner, E-C., Klinke, A., Atzler, D., Slocum, J. L., Lund, N., Kielstein, J. T., Maas, R., Schmidt-Haupt, R., Pekarova, M., Hellwinkel, O., Tsikas, D., D'Alecy, L. G., Lau, D., Willems, S., Kubala, L., Ehmke, H., Meinertz, T., Blankenberg, S., Schwedhelm, E., ... Sydow, K. (2011). Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. CIRCULATION, 124(24), 2735-2745. [24]. http://www.ncbi.nlm.nih.gov/pubmed/22082678?dopt=Citation

Vancouver

von Leitner E-C, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT et al. Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. CIRCULATION. 2011;124(24):2735-2745. 24.

Bibtex

@article{edc697b06aaf4ce89ba5e9929551551a,
title = "Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.",
abstract = "The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.",
keywords = "Animals, Humans, Male, Female, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Mice, Transgenic, Dose-Response Relationship, Drug, Amidohydrolases/genetics/metabolism, Arginine/*analogs & derivatives/pharmacology, Cardiovascular Diseases/metabolism/physiopathology, HL-60 Cells, Neutrophils/cytology/*drug effects/*metabolism, Nitric Oxide/metabolism, Nitric Oxide Synthase Type III/*antagonists & inhibitors, Peroxidase/deficiency/genetics/*metabolism, Signal Transduction/physiology, Superoxides/metabolism, Animals, Humans, Male, Female, Mice, Mice, Inbred C57BL, Mice, Knockout, Models, Animal, Mice, Transgenic, Dose-Response Relationship, Drug, Amidohydrolases/genetics/metabolism, Arginine/*analogs & derivatives/pharmacology, Cardiovascular Diseases/metabolism/physiopathology, HL-60 Cells, Neutrophils/cytology/*drug effects/*metabolism, Nitric Oxide/metabolism, Nitric Oxide Synthase Type III/*antagonists & inhibitors, Peroxidase/deficiency/genetics/*metabolism, Signal Transduction/physiology, Superoxides/metabolism",
author = "{von Leitner}, Eike-Christin and Anna Klinke and Dorothee Atzler and Slocum, {Jessica L} and Natalie Lund and Kielstein, {Jan T} and Renke Maas and Robin Schmidt-Haupt and Michaela Pekarova and Olaf Hellwinkel and Dimitrios Tsikas and D'Alecy, {Louis G} and Denise Lau and Stephan Willems and Lukas Kubala and Heimo Ehmke and Thomas Meinertz and Stefan Blankenberg and Edzard Schwedhelm and Gadegbeku, {Crystal A} and Rainer B{\"o}ger and Stephan Baldus and Karsten Sydow",
year = "2011",
language = "English",
volume = "124",
pages = "2735--2745",
journal = "CIRCULATION",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "24",

}

RIS

TY - JOUR

T1 - Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.

AU - von Leitner, Eike-Christin

AU - Klinke, Anna

AU - Atzler, Dorothee

AU - Slocum, Jessica L

AU - Lund, Natalie

AU - Kielstein, Jan T

AU - Maas, Renke

AU - Schmidt-Haupt, Robin

AU - Pekarova, Michaela

AU - Hellwinkel, Olaf

AU - Tsikas, Dimitrios

AU - D'Alecy, Louis G

AU - Lau, Denise

AU - Willems, Stephan

AU - Kubala, Lukas

AU - Ehmke, Heimo

AU - Meinertz, Thomas

AU - Blankenberg, Stefan

AU - Schwedhelm, Edzard

AU - Gadegbeku, Crystal A

AU - Böger, Rainer

AU - Baldus, Stephan

AU - Sydow, Karsten

PY - 2011

Y1 - 2011

N2 - The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.

AB - The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.

KW - Animals

KW - Humans

KW - Male

KW - Female

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Models, Animal

KW - Mice, Transgenic

KW - Dose-Response Relationship, Drug

KW - Amidohydrolases/genetics/metabolism

KW - Arginine/analogs & derivatives/pharmacology

KW - Cardiovascular Diseases/metabolism/physiopathology

KW - HL-60 Cells

KW - Neutrophils/cytology/drug effects/metabolism

KW - Nitric Oxide/metabolism

KW - Nitric Oxide Synthase Type III/antagonists & inhibitors

KW - Peroxidase/deficiency/genetics/metabolism

KW - Signal Transduction/physiology

KW - Superoxides/metabolism

KW - Animals

KW - Humans

KW - Male

KW - Female

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Models, Animal

KW - Mice, Transgenic

KW - Dose-Response Relationship, Drug

KW - Amidohydrolases/genetics/metabolism

KW - Arginine/analogs & derivatives/pharmacology

KW - Cardiovascular Diseases/metabolism/physiopathology

KW - HL-60 Cells

KW - Neutrophils/cytology/drug effects/metabolism

KW - Nitric Oxide/metabolism

KW - Nitric Oxide Synthase Type III/antagonists & inhibitors

KW - Peroxidase/deficiency/genetics/metabolism

KW - Signal Transduction/physiology

KW - Superoxides/metabolism

M3 - SCORING: Journal article

VL - 124

SP - 2735

EP - 2745

JO - CIRCULATION

JF - CIRCULATION

SN - 0009-7322

IS - 24

M1 - 24

ER -