Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
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Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase. / von Leitner, Eike-Christin; Klinke, Anna; Atzler, Dorothee; Slocum, Jessica L; Lund, Natalie; Kielstein, Jan T; Maas, Renke; Schmidt-Haupt, Robin; Pekarova, Michaela; Hellwinkel, Olaf; Tsikas, Dimitrios; D'Alecy, Louis G; Lau, Denise; Willems, Stephan; Kubala, Lukas; Ehmke, Heimo; Meinertz, Thomas; Blankenberg, Stefan; Schwedhelm, Edzard; Gadegbeku, Crystal A; Böger, Rainer; Baldus, Stephan; Sydow, Karsten.
in: CIRCULATION, Jahrgang 124, Nr. 24, 24, 2011, S. 2735-2745.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
AU - von Leitner, Eike-Christin
AU - Klinke, Anna
AU - Atzler, Dorothee
AU - Slocum, Jessica L
AU - Lund, Natalie
AU - Kielstein, Jan T
AU - Maas, Renke
AU - Schmidt-Haupt, Robin
AU - Pekarova, Michaela
AU - Hellwinkel, Olaf
AU - Tsikas, Dimitrios
AU - D'Alecy, Louis G
AU - Lau, Denise
AU - Willems, Stephan
AU - Kubala, Lukas
AU - Ehmke, Heimo
AU - Meinertz, Thomas
AU - Blankenberg, Stefan
AU - Schwedhelm, Edzard
AU - Gadegbeku, Crystal A
AU - Böger, Rainer
AU - Baldus, Stephan
AU - Sydow, Karsten
PY - 2011
Y1 - 2011
N2 - The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.
AB - The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. The aim of the study was to investigate a potential 2-way interaction between ADMA and MPO.
KW - Animals
KW - Humans
KW - Male
KW - Female
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Animal
KW - Mice, Transgenic
KW - Dose-Response Relationship, Drug
KW - Amidohydrolases/genetics/metabolism
KW - Arginine/analogs & derivatives/pharmacology
KW - Cardiovascular Diseases/metabolism/physiopathology
KW - HL-60 Cells
KW - Neutrophils/cytology/drug effects/metabolism
KW - Nitric Oxide/metabolism
KW - Nitric Oxide Synthase Type III/antagonists & inhibitors
KW - Peroxidase/deficiency/genetics/metabolism
KW - Signal Transduction/physiology
KW - Superoxides/metabolism
KW - Animals
KW - Humans
KW - Male
KW - Female
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Models, Animal
KW - Mice, Transgenic
KW - Dose-Response Relationship, Drug
KW - Amidohydrolases/genetics/metabolism
KW - Arginine/analogs & derivatives/pharmacology
KW - Cardiovascular Diseases/metabolism/physiopathology
KW - HL-60 Cells
KW - Neutrophils/cytology/drug effects/metabolism
KW - Nitric Oxide/metabolism
KW - Nitric Oxide Synthase Type III/antagonists & inhibitors
KW - Peroxidase/deficiency/genetics/metabolism
KW - Signal Transduction/physiology
KW - Superoxides/metabolism
M3 - SCORING: Journal article
VL - 124
SP - 2735
EP - 2745
JO - CIRCULATION
JF - CIRCULATION
SN - 0009-7322
IS - 24
M1 - 24
ER -