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Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine

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Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine. / Marks, Florian; von Kalckreuth, Vera; Kobbe, Robin; Adjei, Samuel; Adjei, Ohene; Horstmann, Rolf D; Meyer, Christian G; May, Jurgen.

In: J INFECT DIS, Vol. 192, No. 11, 01.12.2005, p. 1962-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Marks, F, von Kalckreuth, V, Kobbe, R, Adjei, S, Adjei, O, Horstmann, RD, Meyer, CG & May, J 2005, 'Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine', J INFECT DIS, vol. 192, no. 11, pp. 1962-5. https://doi.org/10.1086/497698

APA

Marks, F., von Kalckreuth, V., Kobbe, R., Adjei, S., Adjei, O., Horstmann, R. D., Meyer, C. G., & May, J. (2005). Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine. J INFECT DIS, 192(11), 1962-5. https://doi.org/10.1086/497698

Vancouver

Marks F, von Kalckreuth V, Kobbe R, Adjei S, Adjei O, Horstmann RD et al. Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine. J INFECT DIS. 2005 Dec 1;192(11):1962-5. https://doi.org/10.1086/497698

Bibtex

@article{0349419047c5427981dd5969b1f47052,
title = "Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine",
abstract = "Intermittent preventive treatment for malaria in infants (IPTi) is a promising malaria control strategy. However, mass preventive treatment for malaria inherently bears the risk of increasing drug resistance. Here, the effect of single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium falciparum infection rates was assessed in 63 selected infants who were aparasitemic at enrollment. An increase in the proportion of infants with isolates exhibiting drug resistance-associated mutations was detected 3 weeks after drug application in the treatment group. S-P, in the setting of IPTi, appears to cause a parasitological rebound effect in which there is selection of drug-resistant parasites for a short period after drug clearance.",
keywords = "Animals, Antimalarials, Drug Combinations, Drug Resistance, Humans, Infant, Malaria, Falciparum, Plasmodium falciparum, Pyrimethamine, Sulfadoxine",
author = "Florian Marks and {von Kalckreuth}, Vera and Robin Kobbe and Samuel Adjei and Ohene Adjei and Horstmann, {Rolf D} and Meyer, {Christian G} and Jurgen May",
year = "2005",
month = dec,
day = "1",
doi = "10.1086/497698",
language = "English",
volume = "192",
pages = "1962--5",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine

AU - Marks, Florian

AU - von Kalckreuth, Vera

AU - Kobbe, Robin

AU - Adjei, Samuel

AU - Adjei, Ohene

AU - Horstmann, Rolf D

AU - Meyer, Christian G

AU - May, Jurgen

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Intermittent preventive treatment for malaria in infants (IPTi) is a promising malaria control strategy. However, mass preventive treatment for malaria inherently bears the risk of increasing drug resistance. Here, the effect of single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium falciparum infection rates was assessed in 63 selected infants who were aparasitemic at enrollment. An increase in the proportion of infants with isolates exhibiting drug resistance-associated mutations was detected 3 weeks after drug application in the treatment group. S-P, in the setting of IPTi, appears to cause a parasitological rebound effect in which there is selection of drug-resistant parasites for a short period after drug clearance.

AB - Intermittent preventive treatment for malaria in infants (IPTi) is a promising malaria control strategy. However, mass preventive treatment for malaria inherently bears the risk of increasing drug resistance. Here, the effect of single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium falciparum infection rates was assessed in 63 selected infants who were aparasitemic at enrollment. An increase in the proportion of infants with isolates exhibiting drug resistance-associated mutations was detected 3 weeks after drug application in the treatment group. S-P, in the setting of IPTi, appears to cause a parasitological rebound effect in which there is selection of drug-resistant parasites for a short period after drug clearance.

KW - Animals

KW - Antimalarials

KW - Drug Combinations

KW - Drug Resistance

KW - Humans

KW - Infant

KW - Malaria, Falciparum

KW - Plasmodium falciparum

KW - Pyrimethamine

KW - Sulfadoxine

U2 - 10.1086/497698

DO - 10.1086/497698

M3 - SCORING: Journal article

C2 - 16267768

VL - 192

SP - 1962

EP - 1965

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 11

ER -