Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine
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Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine. / Marks, Florian; von Kalckreuth, Vera; Kobbe, Robin; Adjei, Samuel; Adjei, Ohene; Horstmann, Rolf D; Meyer, Christian G; May, Jurgen.
in: J INFECT DIS, Jahrgang 192, Nr. 11, 01.12.2005, S. 1962-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine
AU - Marks, Florian
AU - von Kalckreuth, Vera
AU - Kobbe, Robin
AU - Adjei, Samuel
AU - Adjei, Ohene
AU - Horstmann, Rolf D
AU - Meyer, Christian G
AU - May, Jurgen
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Intermittent preventive treatment for malaria in infants (IPTi) is a promising malaria control strategy. However, mass preventive treatment for malaria inherently bears the risk of increasing drug resistance. Here, the effect of single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium falciparum infection rates was assessed in 63 selected infants who were aparasitemic at enrollment. An increase in the proportion of infants with isolates exhibiting drug resistance-associated mutations was detected 3 weeks after drug application in the treatment group. S-P, in the setting of IPTi, appears to cause a parasitological rebound effect in which there is selection of drug-resistant parasites for a short period after drug clearance.
AB - Intermittent preventive treatment for malaria in infants (IPTi) is a promising malaria control strategy. However, mass preventive treatment for malaria inherently bears the risk of increasing drug resistance. Here, the effect of single-dose sulfadoxine-pyrimethamine (S-P) versus placebo on Plasmodium falciparum infection rates was assessed in 63 selected infants who were aparasitemic at enrollment. An increase in the proportion of infants with isolates exhibiting drug resistance-associated mutations was detected 3 weeks after drug application in the treatment group. S-P, in the setting of IPTi, appears to cause a parasitological rebound effect in which there is selection of drug-resistant parasites for a short period after drug clearance.
KW - Animals
KW - Antimalarials
KW - Drug Combinations
KW - Drug Resistance
KW - Humans
KW - Infant
KW - Malaria, Falciparum
KW - Plasmodium falciparum
KW - Pyrimethamine
KW - Sulfadoxine
U2 - 10.1086/497698
DO - 10.1086/497698
M3 - SCORING: Journal article
C2 - 16267768
VL - 192
SP - 1962
EP - 1965
JO - J INFECT DIS
JF - J INFECT DIS
SN - 0022-1899
IS - 11
ER -