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Pancreatic iron and fat, early indicators of impaired glucose metabolism?

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Pancreatic iron and fat, early indicators of impaired glucose metabolism? / Grosse, Regine; Berliner, Christoph; Hainmann, Ina; Weyhmiller, Marcella; Fung, Ellen; Schönnagel, Björn; Yamamura, Jin; Nielsen, Peter; Fischer, Roland.

ABSTRACT BOOK. 2018.

Research output: SCORING: Contribution to book/anthology › Conference contribution - Poster › Research

Harvard

Grosse, R, Berliner, C, Hainmann, I, Weyhmiller, M, Fung, E, Schönnagel, B, Yamamura, J, Nielsen, P & Fischer, R 2018, Pancreatic iron and fat, early indicators of impaired glucose metabolism? in ABSTRACT BOOK. EUROPEAN IRON CLUB ANNUAL MEETING 2018, Zürich, Switzerland, 08.02.18. https://doi.org/10.13140/RG.2.2.28681.34400

APA

Grosse, R., Berliner, C., Hainmann, I., Weyhmiller, M., Fung, E., Schönnagel, B., Yamamura, J., Nielsen, P., & Fischer, R. (2018). Pancreatic iron and fat, early indicators of impaired glucose metabolism? In ABSTRACT BOOK https://doi.org/10.13140/RG.2.2.28681.34400

Vancouver

Grosse R, Berliner C, Hainmann I, Weyhmiller M, Fung E, Schönnagel B et al. Pancreatic iron and fat, early indicators of impaired glucose metabolism? In ABSTRACT BOOK. 2018 https://doi.org/10.13140/RG.2.2.28681.34400

Bibtex

@inbook{44628ca834de43afa0412b3e991835fd,
title = "Pancreatic iron and fat, early indicators of impaired glucose metabolism?",
abstract = "In patients with iron overload (e.g., hemochromatosis, thalassemia, DBA), elevated pancreatic iron levels and fat infiltration are frequently observed. In transfusion dependent thalassemia (TDT) patients, diabetes mellitus (DM) develops after the age of 20 y with a prevalence of 6% to 50% depending on age, ethnicity and chelation treatment regimen. Objective: To quantitatively explore the relationship between pancreatic iron or fat content and parameters of glucose metabolism in patients undergoing regular iron monitoring of liver, heart, and pancreas by biomagnetometry and MRI. Materials and Methods: Pancreatic iron (R2*) and fat content (FC) were measured by standard gradient echo sequences and analyzed by chemical-shift relaxometry (= echo time dependent signal magnitude fit). Timely correlated glucose and insulin kinetics could be studied by oral glucose tolerance tests (oGTT) in 19 patient measurements. The following parameters were determined: fasting glucose level (G-0), HOMA index, and the model derived oral glucose insulin sensitivity (OGIS) index (Mari et al, 2001). Results: Mean pancreatic R2* rate and FC were obtained as 240±195s -1 (in vivo iron concentrations of about 1000±800μg/g) and 28±18%, respectively. The highest R2* rate (660s -1 ) was found in a patient with IGT/DM. Pancreatic R2* significantly correlated with G-0 or OGIS (p<0.01) but FC did not correlate. Bivariate prediction of OGIS was found to be significant (r 2 =0.61) for both R2* (p=0.002) and FC (p=0.02). Conclusion: Pancreatic iron and fat content does not only indicate end-stage impaired glucose tolerance but may also predict the risk of developing diabetes in patients with iron overload early on.",
author = "Regine Grosse and Christoph Berliner and Ina Hainmann and Marcella Weyhmiller and Ellen Fung and Bj{\"o}rn Sch{\"o}nnagel and Jin Yamamura and Peter Nielsen and Roland Fischer",
year = "2018",
month = feb,
day = "10",
doi = "10.13140/RG.2.2.28681.34400",
language = "Deutsch",
booktitle = "ABSTRACT BOOK",
note = "EUROPEAN IRON CLUB ANNUAL MEETING 2018 ; Conference date: 08-02-2018 Through 11-02-2018",

}

RIS

TY - CHAP

T1 - Pancreatic iron and fat, early indicators of impaired glucose metabolism?

AU - Grosse, Regine

AU - Berliner, Christoph

AU - Hainmann, Ina

AU - Weyhmiller, Marcella

AU - Fung, Ellen

AU - Schönnagel, Björn

AU - Yamamura, Jin

AU - Nielsen, Peter

AU - Fischer, Roland

PY - 2018/2/10

Y1 - 2018/2/10

N2 - In patients with iron overload (e.g., hemochromatosis, thalassemia, DBA), elevated pancreatic iron levels and fat infiltration are frequently observed. In transfusion dependent thalassemia (TDT) patients, diabetes mellitus (DM) develops after the age of 20 y with a prevalence of 6% to 50% depending on age, ethnicity and chelation treatment regimen. Objective: To quantitatively explore the relationship between pancreatic iron or fat content and parameters of glucose metabolism in patients undergoing regular iron monitoring of liver, heart, and pancreas by biomagnetometry and MRI. Materials and Methods: Pancreatic iron (R2*) and fat content (FC) were measured by standard gradient echo sequences and analyzed by chemical-shift relaxometry (= echo time dependent signal magnitude fit). Timely correlated glucose and insulin kinetics could be studied by oral glucose tolerance tests (oGTT) in 19 patient measurements. The following parameters were determined: fasting glucose level (G-0), HOMA index, and the model derived oral glucose insulin sensitivity (OGIS) index (Mari et al, 2001). Results: Mean pancreatic R2* rate and FC were obtained as 240±195s -1 (in vivo iron concentrations of about 1000±800μg/g) and 28±18%, respectively. The highest R2* rate (660s -1 ) was found in a patient with IGT/DM. Pancreatic R2* significantly correlated with G-0 or OGIS (p<0.01) but FC did not correlate. Bivariate prediction of OGIS was found to be significant (r 2 =0.61) for both R2* (p=0.002) and FC (p=0.02). Conclusion: Pancreatic iron and fat content does not only indicate end-stage impaired glucose tolerance but may also predict the risk of developing diabetes in patients with iron overload early on.

AB - In patients with iron overload (e.g., hemochromatosis, thalassemia, DBA), elevated pancreatic iron levels and fat infiltration are frequently observed. In transfusion dependent thalassemia (TDT) patients, diabetes mellitus (DM) develops after the age of 20 y with a prevalence of 6% to 50% depending on age, ethnicity and chelation treatment regimen. Objective: To quantitatively explore the relationship between pancreatic iron or fat content and parameters of glucose metabolism in patients undergoing regular iron monitoring of liver, heart, and pancreas by biomagnetometry and MRI. Materials and Methods: Pancreatic iron (R2*) and fat content (FC) were measured by standard gradient echo sequences and analyzed by chemical-shift relaxometry (= echo time dependent signal magnitude fit). Timely correlated glucose and insulin kinetics could be studied by oral glucose tolerance tests (oGTT) in 19 patient measurements. The following parameters were determined: fasting glucose level (G-0), HOMA index, and the model derived oral glucose insulin sensitivity (OGIS) index (Mari et al, 2001). Results: Mean pancreatic R2* rate and FC were obtained as 240±195s -1 (in vivo iron concentrations of about 1000±800μg/g) and 28±18%, respectively. The highest R2* rate (660s -1 ) was found in a patient with IGT/DM. Pancreatic R2* significantly correlated with G-0 or OGIS (p<0.01) but FC did not correlate. Bivariate prediction of OGIS was found to be significant (r 2 =0.61) for both R2* (p=0.002) and FC (p=0.02). Conclusion: Pancreatic iron and fat content does not only indicate end-stage impaired glucose tolerance but may also predict the risk of developing diabetes in patients with iron overload early on.

U2 - 10.13140/RG.2.2.28681.34400

DO - 10.13140/RG.2.2.28681.34400

M3 - Konferenzbeitrag - Poster

BT - ABSTRACT BOOK

T2 - EUROPEAN IRON CLUB ANNUAL MEETING 2018

Y2 - 8 February 2018 through 11 February 2018

ER -