Pancreatic iron and fat, early indicators of impaired glucose metabolism?
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Pancreatic iron and fat, early indicators of impaired glucose metabolism? / Grosse, Regine; Berliner, Christoph; Hainmann, Ina; Weyhmiller, Marcella; Fung, Ellen; Schönnagel, Björn; Yamamura, Jin; Nielsen, Peter; Fischer, Roland.
ABSTRACT BOOK. 2018.Publikationen: SCORING: Beitrag in Buch/Sammelwerk › Konferenzbeitrag - Poster › Forschung
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T1 - Pancreatic iron and fat, early indicators of impaired glucose metabolism?
AU - Grosse, Regine
AU - Berliner, Christoph
AU - Hainmann, Ina
AU - Weyhmiller, Marcella
AU - Fung, Ellen
AU - Schönnagel, Björn
AU - Yamamura, Jin
AU - Nielsen, Peter
AU - Fischer, Roland
PY - 2018/2/10
Y1 - 2018/2/10
N2 - In patients with iron overload (e.g., hemochromatosis, thalassemia, DBA), elevated pancreatic iron levels and fat infiltration are frequently observed. In transfusion dependent thalassemia (TDT) patients, diabetes mellitus (DM) develops after the age of 20 y with a prevalence of 6% to 50% depending on age, ethnicity and chelation treatment regimen. Objective: To quantitatively explore the relationship between pancreatic iron or fat content and parameters of glucose metabolism in patients undergoing regular iron monitoring of liver, heart, and pancreas by biomagnetometry and MRI. Materials and Methods: Pancreatic iron (R2*) and fat content (FC) were measured by standard gradient echo sequences and analyzed by chemical-shift relaxometry (= echo time dependent signal magnitude fit). Timely correlated glucose and insulin kinetics could be studied by oral glucose tolerance tests (oGTT) in 19 patient measurements. The following parameters were determined: fasting glucose level (G-0), HOMA index, and the model derived oral glucose insulin sensitivity (OGIS) index (Mari et al, 2001). Results: Mean pancreatic R2* rate and FC were obtained as 240±195s -1 (in vivo iron concentrations of about 1000±800μg/g) and 28±18%, respectively. The highest R2* rate (660s -1 ) was found in a patient with IGT/DM. Pancreatic R2* significantly correlated with G-0 or OGIS (p<0.01) but FC did not correlate. Bivariate prediction of OGIS was found to be significant (r 2 =0.61) for both R2* (p=0.002) and FC (p=0.02). Conclusion: Pancreatic iron and fat content does not only indicate end-stage impaired glucose tolerance but may also predict the risk of developing diabetes in patients with iron overload early on.
AB - In patients with iron overload (e.g., hemochromatosis, thalassemia, DBA), elevated pancreatic iron levels and fat infiltration are frequently observed. In transfusion dependent thalassemia (TDT) patients, diabetes mellitus (DM) develops after the age of 20 y with a prevalence of 6% to 50% depending on age, ethnicity and chelation treatment regimen. Objective: To quantitatively explore the relationship between pancreatic iron or fat content and parameters of glucose metabolism in patients undergoing regular iron monitoring of liver, heart, and pancreas by biomagnetometry and MRI. Materials and Methods: Pancreatic iron (R2*) and fat content (FC) were measured by standard gradient echo sequences and analyzed by chemical-shift relaxometry (= echo time dependent signal magnitude fit). Timely correlated glucose and insulin kinetics could be studied by oral glucose tolerance tests (oGTT) in 19 patient measurements. The following parameters were determined: fasting glucose level (G-0), HOMA index, and the model derived oral glucose insulin sensitivity (OGIS) index (Mari et al, 2001). Results: Mean pancreatic R2* rate and FC were obtained as 240±195s -1 (in vivo iron concentrations of about 1000±800μg/g) and 28±18%, respectively. The highest R2* rate (660s -1 ) was found in a patient with IGT/DM. Pancreatic R2* significantly correlated with G-0 or OGIS (p<0.01) but FC did not correlate. Bivariate prediction of OGIS was found to be significant (r 2 =0.61) for both R2* (p=0.002) and FC (p=0.02). Conclusion: Pancreatic iron and fat content does not only indicate end-stage impaired glucose tolerance but may also predict the risk of developing diabetes in patients with iron overload early on.
U2 - 10.13140/RG.2.2.28681.34400
DO - 10.13140/RG.2.2.28681.34400
M3 - Konferenzbeitrag - Poster
BT - ABSTRACT BOOK
T2 - EUROPEAN IRON CLUB ANNUAL MEETING 2018
Y2 - 8 February 2018 through 11 February 2018
ER -