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Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives

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Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives. / Sinning, Christoph; Westermann, Dirk; Clemmensen, Peter.

In: BIOMARK MED, Vol. 11, No. 11, 11.2017, p. 1031-1040.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Sinning, C, Westermann, D & Clemmensen, P 2017, 'Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives', BIOMARK MED, vol. 11, no. 11, pp. 1031-1040. https://doi.org/10.2217/bmm-2017-0110

APA

Sinning, C., Westermann, D., & Clemmensen, P. (2017). Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives. BIOMARK MED, 11(11), 1031-1040. https://doi.org/10.2217/bmm-2017-0110

Vancouver

Sinning C, Westermann D, Clemmensen P. Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives. BIOMARK MED. 2017 Nov;11(11):1031-1040. https://doi.org/10.2217/bmm-2017-0110

Bibtex

@article{555fb8714be84baab798f64fd1932b32,
title = "Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives",
abstract = "Oxidative stress remains a major contributor to myocardial injury after ischemia followed by reperfusion (I/R) as the reperfusion of the myocardial infarction (MI) area inevitably leads to a cascade of I/R injury. This review focused on concepts of the antioxidative defense system and elucidates recent research using antioxidants like vitamin C, E and β-carotene or essential trace elements to activate compounds of antioxidative pathways in the circulation. In this context, important defense mechanisms like superoxide dismutase and glutathione peroxidase will be described. Furthermore, the different mechanisms through which myocardial protection can be addressed, like ischemic postconditioning in myocardial infarction or adjunctive measures like targeted temperature management as well as new theories, including the role of iron in I/R injury, will be discussed.",
keywords = "Animals, Humans, Ischemic Postconditioning, Myocardial Infarction/metabolism, Myocardial Reperfusion Injury/metabolism, Myocardium/metabolism, Oxidative Stress",
author = "Christoph Sinning and Dirk Westermann and Peter Clemmensen",
year = "2017",
month = nov,
doi = "10.2217/bmm-2017-0110",
language = "English",
volume = "11",
pages = "1031--1040",
journal = "BIOMARK MED",
issn = "1752-0363",
publisher = "Future Medicine Ltd",
number = "11",

}

RIS

TY - JOUR

T1 - Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives

AU - Sinning, Christoph

AU - Westermann, Dirk

AU - Clemmensen, Peter

PY - 2017/11

Y1 - 2017/11

N2 - Oxidative stress remains a major contributor to myocardial injury after ischemia followed by reperfusion (I/R) as the reperfusion of the myocardial infarction (MI) area inevitably leads to a cascade of I/R injury. This review focused on concepts of the antioxidative defense system and elucidates recent research using antioxidants like vitamin C, E and β-carotene or essential trace elements to activate compounds of antioxidative pathways in the circulation. In this context, important defense mechanisms like superoxide dismutase and glutathione peroxidase will be described. Furthermore, the different mechanisms through which myocardial protection can be addressed, like ischemic postconditioning in myocardial infarction or adjunctive measures like targeted temperature management as well as new theories, including the role of iron in I/R injury, will be discussed.

AB - Oxidative stress remains a major contributor to myocardial injury after ischemia followed by reperfusion (I/R) as the reperfusion of the myocardial infarction (MI) area inevitably leads to a cascade of I/R injury. This review focused on concepts of the antioxidative defense system and elucidates recent research using antioxidants like vitamin C, E and β-carotene or essential trace elements to activate compounds of antioxidative pathways in the circulation. In this context, important defense mechanisms like superoxide dismutase and glutathione peroxidase will be described. Furthermore, the different mechanisms through which myocardial protection can be addressed, like ischemic postconditioning in myocardial infarction or adjunctive measures like targeted temperature management as well as new theories, including the role of iron in I/R injury, will be discussed.

KW - Animals

KW - Humans

KW - Ischemic Postconditioning

KW - Myocardial Infarction/metabolism

KW - Myocardial Reperfusion Injury/metabolism

KW - Myocardium/metabolism

KW - Oxidative Stress

U2 - 10.2217/bmm-2017-0110

DO - 10.2217/bmm-2017-0110

M3 - SCORING: Review article

C2 - 29039206

VL - 11

SP - 1031

EP - 1040

JO - BIOMARK MED

JF - BIOMARK MED

SN - 1752-0363

IS - 11

ER -