Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives
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Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives. / Sinning, Christoph; Westermann, Dirk; Clemmensen, Peter.
in: BIOMARK MED, Jahrgang 11, Nr. 11, 11.2017, S. 1031-1040.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives
AU - Sinning, Christoph
AU - Westermann, Dirk
AU - Clemmensen, Peter
PY - 2017/11
Y1 - 2017/11
N2 - Oxidative stress remains a major contributor to myocardial injury after ischemia followed by reperfusion (I/R) as the reperfusion of the myocardial infarction (MI) area inevitably leads to a cascade of I/R injury. This review focused on concepts of the antioxidative defense system and elucidates recent research using antioxidants like vitamin C, E and β-carotene or essential trace elements to activate compounds of antioxidative pathways in the circulation. In this context, important defense mechanisms like superoxide dismutase and glutathione peroxidase will be described. Furthermore, the different mechanisms through which myocardial protection can be addressed, like ischemic postconditioning in myocardial infarction or adjunctive measures like targeted temperature management as well as new theories, including the role of iron in I/R injury, will be discussed.
AB - Oxidative stress remains a major contributor to myocardial injury after ischemia followed by reperfusion (I/R) as the reperfusion of the myocardial infarction (MI) area inevitably leads to a cascade of I/R injury. This review focused on concepts of the antioxidative defense system and elucidates recent research using antioxidants like vitamin C, E and β-carotene or essential trace elements to activate compounds of antioxidative pathways in the circulation. In this context, important defense mechanisms like superoxide dismutase and glutathione peroxidase will be described. Furthermore, the different mechanisms through which myocardial protection can be addressed, like ischemic postconditioning in myocardial infarction or adjunctive measures like targeted temperature management as well as new theories, including the role of iron in I/R injury, will be discussed.
KW - Animals
KW - Humans
KW - Ischemic Postconditioning
KW - Myocardial Infarction/metabolism
KW - Myocardial Reperfusion Injury/metabolism
KW - Myocardium/metabolism
KW - Oxidative Stress
U2 - 10.2217/bmm-2017-0110
DO - 10.2217/bmm-2017-0110
M3 - SCORING: Review article
C2 - 29039206
VL - 11
SP - 1031
EP - 1040
JO - BIOMARK MED
JF - BIOMARK MED
SN - 1752-0363
IS - 11
ER -