Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect
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Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect. / Böttinger, Boris William; Baumeister, Sarah; Millenet, Sabina; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Artiges, Eric; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Banaschewski, Tobias; Brandeis, Daniel; Nees, Frauke; IMAGEN Consortium.
In: EUR CHILD ADOLES PSY, Vol. 31, No. 8, 08.2022, p. 1-10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect
AU - Böttinger, Boris William
AU - Baumeister, Sarah
AU - Millenet, Sabina
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Büchel, Christian
AU - Quinlan, Erin Burke
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean-Luc
AU - Martinot, Marie-Laure Paillère
AU - Artiges, Eric
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Fröhner, Juliane H
AU - Smolka, Michael N
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Banaschewski, Tobias
AU - Brandeis, Daniel
AU - Nees, Frauke
AU - IMAGEN Consortium
PY - 2022/8
Y1 - 2022/8
N2 - Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents.
AB - Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents.
U2 - 10.1007/s00787-021-01770-1
DO - 10.1007/s00787-021-01770-1
M3 - SCORING: Journal article
C2 - 33861383
VL - 31
SP - 1
EP - 10
JO - EUR CHILD ADOLES PSY
JF - EUR CHILD ADOLES PSY
SN - 1018-8827
IS - 8
ER -