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Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect

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Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect. / Böttinger, Boris William; Baumeister, Sarah; Millenet, Sabina; Barker, Gareth J; Bokde, Arun L W; Büchel, Christian; Quinlan, Erin Burke; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Artiges, Eric; Orfanos, Dimitri Papadopoulos; Paus, Tomáš; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Banaschewski, Tobias; Brandeis, Daniel; Nees, Frauke; IMAGEN Consortium.

in: EUR CHILD ADOLES PSY, Jahrgang 31, Nr. 8, 08.2022, S. 1-10.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Böttinger, BW, Baumeister, S, Millenet, S, Barker, GJ, Bokde, ALW, Büchel, C, Quinlan, EB, Desrivières, S, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, J-L, Martinot, M-LP, Artiges, E, Orfanos, DP, Paus, T, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Banaschewski, T, Brandeis, D, Nees, F & IMAGEN Consortium 2022, 'Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect', EUR CHILD ADOLES PSY, Jg. 31, Nr. 8, S. 1-10. https://doi.org/10.1007/s00787-021-01770-1

APA

Böttinger, B. W., Baumeister, S., Millenet, S., Barker, G. J., Bokde, A. L. W., Büchel, C., Quinlan, E. B., Desrivières, S., Flor, H., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J-L., Martinot, M-L. P., Artiges, E., Orfanos, D. P., Paus, T., ... IMAGEN Consortium (2022). Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect. EUR CHILD ADOLES PSY, 31(8), 1-10. https://doi.org/10.1007/s00787-021-01770-1

Vancouver

Böttinger BW, Baumeister S, Millenet S, Barker GJ, Bokde ALW, Büchel C et al. Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect. EUR CHILD ADOLES PSY. 2022 Aug;31(8):1-10. https://doi.org/10.1007/s00787-021-01770-1

Bibtex

@article{75359f2bbb254156aeef8df8d05a933b,
title = "Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect",
abstract = "Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents.",
author = "B{\"o}ttinger, {Boris William} and Sarah Baumeister and Sabina Millenet and Barker, {Gareth J} and Bokde, {Arun L W} and Christian B{\"u}chel and Quinlan, {Erin Burke} and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Eric Artiges and Orfanos, {Dimitri Papadopoulos} and Tom{\'a}{\v s} Paus and Luise Poustka and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Henrik Walter and Robert Whelan and Gunter Schumann and Tobias Banaschewski and Daniel Brandeis and Frauke Nees and {IMAGEN Consortium}",
year = "2022",
month = aug,
doi = "10.1007/s00787-021-01770-1",
language = "English",
volume = "31",
pages = "1--10",
journal = "EUR CHILD ADOLES PSY",
issn = "1018-8827",
publisher = "D. Steinkopff-Verlag",
number = "8",

}

RIS

TY - JOUR

T1 - Orbitofrontal control of conduct problems? Evidence from healthy adolescents processing negative facial affect

AU - Böttinger, Boris William

AU - Baumeister, Sarah

AU - Millenet, Sabina

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Artiges, Eric

AU - Orfanos, Dimitri Papadopoulos

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Banaschewski, Tobias

AU - Brandeis, Daniel

AU - Nees, Frauke

AU - IMAGEN Consortium

PY - 2022/8

Y1 - 2022/8

N2 - Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents.

AB - Conduct problems (CP) in patients with disruptive behavior disorders have been linked to impaired prefrontal processing of negative facial affect compared to controls. However, it is unknown whether associations with prefrontal activity during affective face processing hold along the CP dimension in a healthy population sample, and how subcortical processing is affected. We measured functional brain responses during negative affective face processing in 1444 healthy adolescents [M = 14.39 years (SD = 0.40), 51.5% female] from the European IMAGEN multicenter study. To determine the effects of CP, we applied a two-step approach: (a) testing matched subgroups of low versus high CP, extending into the clinical range [N = 182 per group, M = 14.44 years, (SD = 0.41), 47.3% female] using analysis of variance, and (b) considering (non)linear effects along the CP dimension in the full sample and in the high CP group using multiple regression. We observed no significant cortical or subcortical effect of CP group on brain responses to negative facial affect. In the full sample, regression analyses revealed a significant linear increase of left orbitofrontal cortex (OFC) activity with increasing CP up to the clinical range. In the high CP group, a significant inverted u-shaped effect indicated that left OFC responses decreased again in individuals with high CP. Left OFC activity during negative affective processing which is increasing with CP and decreasing in the highest CP range may reflect on the importance of frontal control mechanisms that counteract the consequences of severe CP by facilitating higher social engagement and better evaluation of social content in adolescents.

U2 - 10.1007/s00787-021-01770-1

DO - 10.1007/s00787-021-01770-1

M3 - SCORING: Journal article

C2 - 33861383

VL - 31

SP - 1

EP - 10

JO - EUR CHILD ADOLES PSY

JF - EUR CHILD ADOLES PSY

SN - 1018-8827

IS - 8

ER -