Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography
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Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography. / Canjau, Silvana; Todea, Carmen; Sinescu, Cosmin; Negrutiu, Meda L.; Duma, Virgil; Manescu, Adrian; Topala, Florin I.; Podoleanu, Adrian Gh.
HEAD AND NECK OPTICAL DIAGNOSTICS. ed. / C Betz; BJF Wong. Vol. 8805 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA : SPIE-INT SOC OPTICAL ENGINEERING, 2013. (Proceedings of SPIE).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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T1 - Optical imaging of oral pathological tissue using optical coherence tomography and synchrotron radiation computed microtomography
AU - Canjau, Silvana
AU - Todea, Carmen
AU - Sinescu, Cosmin
AU - Negrutiu, Meda L.
AU - Duma, Virgil
AU - Manescu, Adrian
AU - Topala, Florin I.
AU - Podoleanu, Adrian Gh.
N1 - 5th Scientific Meeting of the Head-and-Neck-Optical-Diagnostic-Society (HNODS), Munich, GERMANY, MAY 13-14, 2013
PY - 2013
Y1 - 2013
N2 - The efforts aimed at early diagnosis of oral cancer should be prioritized towards developing a new screening instrument, based on optical coherence tomography (OCT), to be used directly intraorally, able to perform a fast, real time, 3D and non-invasive diagnosis of oral malignancies. The first step in this direction would be to optimize the OCT image interpretation of oral tissues. Therefore we propose plastination as a tissue preparation method that better preserves three-dimensional structure for study by new optical imaging techniques. The OCT and the synchrotron radiation computed microtomography (micro-CT) were employed for tissue sample analyze. For validating the OCT results we used the gold standard diagnostic procedure for any suspicious lesion - histopathology. This is a preliminary study of comparing features provided by OCT and Micro-CT. In the conditions of the present study, OCT proves to be a highly promising imaging modality. The use of x-ray based topographic imaging of small biological samples has been limited by the low intrinsic x-ray absorption of non-mineralized tissue and the lack of established contrast agents. Plastination can be used to enhance optical imagies of oral soft tissue samples.
AB - The efforts aimed at early diagnosis of oral cancer should be prioritized towards developing a new screening instrument, based on optical coherence tomography (OCT), to be used directly intraorally, able to perform a fast, real time, 3D and non-invasive diagnosis of oral malignancies. The first step in this direction would be to optimize the OCT image interpretation of oral tissues. Therefore we propose plastination as a tissue preparation method that better preserves three-dimensional structure for study by new optical imaging techniques. The OCT and the synchrotron radiation computed microtomography (micro-CT) were employed for tissue sample analyze. For validating the OCT results we used the gold standard diagnostic procedure for any suspicious lesion - histopathology. This is a preliminary study of comparing features provided by OCT and Micro-CT. In the conditions of the present study, OCT proves to be a highly promising imaging modality. The use of x-ray based topographic imaging of small biological samples has been limited by the low intrinsic x-ray absorption of non-mineralized tissue and the lack of established contrast agents. Plastination can be used to enhance optical imagies of oral soft tissue samples.
KW - Oral squamous cell carcinoma
KW - minimally-invasive diagnosis
KW - plastination
KW - optical coherence tomography
KW - Micro-CT
U2 - 10.1117/12.2032584
DO - 10.1117/12.2032584
M3 - SCORING: Contribution to collected editions/anthologies
SN - 978-0-8194-9813-7
VL - 8805
T3 - Proceedings of SPIE
BT - HEAD AND NECK OPTICAL DIAGNOSTICS
A2 - Betz, C
A2 - Wong, BJF
PB - SPIE-INT SOC OPTICAL ENGINEERING
CY - 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
ER -