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Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

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Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma. / Gakis, Georgios; Efstathiou, Jason A; Daneshmand, Siamak; Keegan, Kirk A; Clayman, Rebecca H; Hrbacek, Jan; Ali-El-Dein, Bedeir; Zaid, Harras B; Schubert, Tina; Mischinger, Johannes; Todenhöfer, Tilman; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George N; Stenzl, Arnulf; Morgan, Todd M.

In: UROL INT, Vol. 97, No. 2, 2016, p. 134-41.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gakis, G, Efstathiou, JA, Daneshmand, S, Keegan, KA, Clayman, RH, Hrbacek, J, Ali-El-Dein, B, Zaid, HB, Schubert, T, Mischinger, J, Todenhöfer, T, Galland, S, Olugbade, K, Rink, M, Fritsche, H-M, Burger, M, Chang, SS, Babjuk, M, Thalmann, GN, Stenzl, A & Morgan, TM 2016, 'Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma', UROL INT, vol. 97, no. 2, pp. 134-41. https://doi.org/10.1159/000448335

APA

Gakis, G., Efstathiou, J. A., Daneshmand, S., Keegan, K. A., Clayman, R. H., Hrbacek, J., Ali-El-Dein, B., Zaid, H. B., Schubert, T., Mischinger, J., Todenhöfer, T., Galland, S., Olugbade, K., Rink, M., Fritsche, H-M., Burger, M., Chang, S. S., Babjuk, M., Thalmann, G. N., ... Morgan, T. M. (2016). Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma. UROL INT, 97(2), 134-41. https://doi.org/10.1159/000448335

Vancouver

Gakis G, Efstathiou JA, Daneshmand S, Keegan KA, Clayman RH, Hrbacek J et al. Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma. UROL INT. 2016;97(2):134-41. https://doi.org/10.1159/000448335

Bibtex

@article{341f8c72932e4f7aaaa7fcd356a4dd7e,
title = "Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma",
abstract = "INTRODUCTION: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma.METHODS: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence.RESULTS: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020).CONCLUSION: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.",
keywords = "Journal Article",
author = "Georgios Gakis and Efstathiou, {Jason A} and Siamak Daneshmand and Keegan, {Kirk A} and Clayman, {Rebecca H} and Jan Hrbacek and Bedeir Ali-El-Dein and Zaid, {Harras B} and Tina Schubert and Johannes Mischinger and Tilman Todenh{\"o}fer and Sigolene Galland and Kola Olugbade and Michael Rink and Hans-Martin Fritsche and Maximilian Burger and Chang, {Sam S} and Marko Babjuk and Thalmann, {George N} and Arnulf Stenzl and Morgan, {Todd M}",
note = "{\textcopyright} 2016 S. Karger AG, Basel.",
year = "2016",
doi = "10.1159/000448335",
language = "English",
volume = "97",
pages = "134--41",
journal = "UROL INT",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma

AU - Gakis, Georgios

AU - Efstathiou, Jason A

AU - Daneshmand, Siamak

AU - Keegan, Kirk A

AU - Clayman, Rebecca H

AU - Hrbacek, Jan

AU - Ali-El-Dein, Bedeir

AU - Zaid, Harras B

AU - Schubert, Tina

AU - Mischinger, Johannes

AU - Todenhöfer, Tilman

AU - Galland, Sigolene

AU - Olugbade, Kola

AU - Rink, Michael

AU - Fritsche, Hans-Martin

AU - Burger, Maximilian

AU - Chang, Sam S

AU - Babjuk, Marko

AU - Thalmann, George N

AU - Stenzl, Arnulf

AU - Morgan, Todd M

N1 - © 2016 S. Karger AG, Basel.

PY - 2016

Y1 - 2016

N2 - INTRODUCTION: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma.METHODS: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence.RESULTS: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020).CONCLUSION: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.

AB - INTRODUCTION: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma.METHODS: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence.RESULTS: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020).CONCLUSION: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.

KW - Journal Article

U2 - 10.1159/000448335

DO - 10.1159/000448335

M3 - SCORING: Journal article

C2 - 27462702

VL - 97

SP - 134

EP - 141

JO - UROL INT

JF - UROL INT

SN - 0042-1138

IS - 2

ER -