Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma
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Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma. / Gakis, Georgios; Efstathiou, Jason A; Daneshmand, Siamak; Keegan, Kirk A; Clayman, Rebecca H; Hrbacek, Jan; Ali-El-Dein, Bedeir; Zaid, Harras B; Schubert, Tina; Mischinger, Johannes; Todenhöfer, Tilman; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George N; Stenzl, Arnulf; Morgan, Todd M.
in: UROL INT, Jahrgang 97, Nr. 2, 2016, S. 134-41.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Oncological Outcomes of Patients with Concomitant Bladder and Urethral Carcinoma
AU - Gakis, Georgios
AU - Efstathiou, Jason A
AU - Daneshmand, Siamak
AU - Keegan, Kirk A
AU - Clayman, Rebecca H
AU - Hrbacek, Jan
AU - Ali-El-Dein, Bedeir
AU - Zaid, Harras B
AU - Schubert, Tina
AU - Mischinger, Johannes
AU - Todenhöfer, Tilman
AU - Galland, Sigolene
AU - Olugbade, Kola
AU - Rink, Michael
AU - Fritsche, Hans-Martin
AU - Burger, Maximilian
AU - Chang, Sam S
AU - Babjuk, Marko
AU - Thalmann, George N
AU - Stenzl, Arnulf
AU - Morgan, Todd M
N1 - © 2016 S. Karger AG, Basel.
PY - 2016
Y1 - 2016
N2 - INTRODUCTION: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma.METHODS: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence.RESULTS: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020).CONCLUSION: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.
AB - INTRODUCTION: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma.METHODS: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence.RESULTS: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48). Urethral cancers were of higher grade in patients with synchronous BC compared to patients with non-synchronous BC (p = 0.020). Patients with synchronous BC exhibited significantly inferior 3-year recurrence-free survival (RFS) compared to patients with non-synchronous BC (63.2 vs. 34.4%; p = 0.026). In multivariable analysis, inferior RFS was associated with clinically advanced nodal stage (p < 0.001), proximal tumor location (p < 0.001) and synchronous BC (p = 0.020).CONCLUSION: The synchronous presence of BC in patients diagnosed with urethral carcinoma has a significant adverse impact on RFS and should be an impetus for a multimodal approach.
KW - Journal Article
U2 - 10.1159/000448335
DO - 10.1159/000448335
M3 - SCORING: Journal article
C2 - 27462702
VL - 97
SP - 134
EP - 141
JO - UROL INT
JF - UROL INT
SN - 0042-1138
IS - 2
ER -