Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
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Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life. / Jacobsen, Henning; Walendy-Gnirß, Kerstin; Tekin-Bubenheim, Nilgün; Kouassi, Nancy Mounogou; Ben-Batalla, Isabel; Berenbrok, Nikolaus; Wolff, Martin; Dos Reis, Vinicius Pinho; Zickler, Martin; Scholl, Lucas; Gries, Annette; Jania, Hanna; Kloetgen, Andreas; Düsedau, Arne; Pilnitz-Stolze, Gundula; Jeridi, Aicha; Yildirim, Ali Önder; Fuchs, Helmut; Gailus-Durner, Valerie; Stoeger, Claudia; de Angelis, Martin Hrabe; Manuylova, Tatjana; Klingel, Karin; Culley, Fiona J; Behrends, Jochen; Loges, Sonja; Schneider, Bianca; Krauss-Etschmann, Susanne; Openshaw, Peter; Gabriel, Gülsah.
In: NAT COMMUN, Vol. 12, No. 1, 16.08.2021, p. 4957.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life
AU - Jacobsen, Henning
AU - Walendy-Gnirß, Kerstin
AU - Tekin-Bubenheim, Nilgün
AU - Kouassi, Nancy Mounogou
AU - Ben-Batalla, Isabel
AU - Berenbrok, Nikolaus
AU - Wolff, Martin
AU - Dos Reis, Vinicius Pinho
AU - Zickler, Martin
AU - Scholl, Lucas
AU - Gries, Annette
AU - Jania, Hanna
AU - Kloetgen, Andreas
AU - Düsedau, Arne
AU - Pilnitz-Stolze, Gundula
AU - Jeridi, Aicha
AU - Yildirim, Ali Önder
AU - Fuchs, Helmut
AU - Gailus-Durner, Valerie
AU - Stoeger, Claudia
AU - de Angelis, Martin Hrabe
AU - Manuylova, Tatjana
AU - Klingel, Karin
AU - Culley, Fiona J
AU - Behrends, Jochen
AU - Loges, Sonja
AU - Schneider, Bianca
AU - Krauss-Etschmann, Susanne
AU - Openshaw, Peter
AU - Gabriel, Gülsah
N1 - © 2021. The Author(s).
PY - 2021/8/16
Y1 - 2021/8/16
N2 - Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.
AB - Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.
KW - Animals
KW - Animals, Newborn
KW - Bacterial Infections/immunology
KW - Disease Models, Animal
KW - Female
KW - Hematopoiesis
KW - Humans
KW - Influenza A virus/immunology
KW - Influenza, Human/immunology
KW - Lung/immunology
KW - Macrophages, Alveolar
KW - Mice
KW - Mice, Inbred C57BL
KW - Mothers
KW - Orthomyxoviridae Infections/virology
KW - Parturition
KW - Poly I-C
KW - Pregnancy
U2 - 10.1038/s41467-021-25220-3
DO - 10.1038/s41467-021-25220-3
M3 - SCORING: Journal article
C2 - 34400653
VL - 12
SP - 4957
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -