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Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

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Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life. / Jacobsen, Henning; Walendy-Gnirß, Kerstin; Tekin-Bubenheim, Nilgün; Kouassi, Nancy Mounogou; Ben-Batalla, Isabel; Berenbrok, Nikolaus; Wolff, Martin; Dos Reis, Vinicius Pinho; Zickler, Martin; Scholl, Lucas; Gries, Annette; Jania, Hanna; Kloetgen, Andreas; Düsedau, Arne; Pilnitz-Stolze, Gundula; Jeridi, Aicha; Yildirim, Ali Önder; Fuchs, Helmut; Gailus-Durner, Valerie; Stoeger, Claudia; de Angelis, Martin Hrabe; Manuylova, Tatjana; Klingel, Karin; Culley, Fiona J; Behrends, Jochen; Loges, Sonja; Schneider, Bianca; Krauss-Etschmann, Susanne; Openshaw, Peter; Gabriel, Gülsah.

in: NAT COMMUN, Jahrgang 12, Nr. 1, 16.08.2021, S. 4957.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jacobsen, H, Walendy-Gnirß, K, Tekin-Bubenheim, N, Kouassi, NM, Ben-Batalla, I, Berenbrok, N, Wolff, M, Dos Reis, VP, Zickler, M, Scholl, L, Gries, A, Jania, H, Kloetgen, A, Düsedau, A, Pilnitz-Stolze, G, Jeridi, A, Yildirim, AÖ, Fuchs, H, Gailus-Durner, V, Stoeger, C, de Angelis, MH, Manuylova, T, Klingel, K, Culley, FJ, Behrends, J, Loges, S, Schneider, B, Krauss-Etschmann, S, Openshaw, P & Gabriel, G 2021, 'Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life', NAT COMMUN, Jg. 12, Nr. 1, S. 4957. https://doi.org/10.1038/s41467-021-25220-3

APA

Jacobsen, H., Walendy-Gnirß, K., Tekin-Bubenheim, N., Kouassi, N. M., Ben-Batalla, I., Berenbrok, N., Wolff, M., Dos Reis, V. P., Zickler, M., Scholl, L., Gries, A., Jania, H., Kloetgen, A., Düsedau, A., Pilnitz-Stolze, G., Jeridi, A., Yildirim, A. Ö., Fuchs, H., Gailus-Durner, V., ... Gabriel, G. (2021). Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life. NAT COMMUN, 12(1), 4957. https://doi.org/10.1038/s41467-021-25220-3

Vancouver

Jacobsen H, Walendy-Gnirß K, Tekin-Bubenheim N, Kouassi NM, Ben-Batalla I, Berenbrok N et al. Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life. NAT COMMUN. 2021 Aug 16;12(1):4957. https://doi.org/10.1038/s41467-021-25220-3

Bibtex

@article{40571afc4b2142e39d305c76c49f3494,
title = "Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life",
abstract = "Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.",
keywords = "Animals, Animals, Newborn, Bacterial Infections/immunology, Disease Models, Animal, Female, Hematopoiesis, Humans, Influenza A virus/immunology, Influenza, Human/immunology, Lung/immunology, Macrophages, Alveolar, Mice, Mice, Inbred C57BL, Mothers, Orthomyxoviridae Infections/virology, Parturition, Poly I-C, Pregnancy",
author = "Henning Jacobsen and Kerstin Walendy-Gnir{\ss} and Nilg{\"u}n Tekin-Bubenheim and Kouassi, {Nancy Mounogou} and Isabel Ben-Batalla and Nikolaus Berenbrok and Martin Wolff and {Dos Reis}, {Vinicius Pinho} and Martin Zickler and Lucas Scholl and Annette Gries and Hanna Jania and Andreas Kloetgen and Arne D{\"u}sedau and Gundula Pilnitz-Stolze and Aicha Jeridi and Yildirim, {Ali {\"O}nder} and Helmut Fuchs and Valerie Gailus-Durner and Claudia Stoeger and {de Angelis}, {Martin Hrabe} and Tatjana Manuylova and Karin Klingel and Culley, {Fiona J} and Jochen Behrends and Sonja Loges and Bianca Schneider and Susanne Krauss-Etschmann and Peter Openshaw and G{\"u}lsah Gabriel",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
day = "16",
doi = "10.1038/s41467-021-25220-3",
language = "English",
volume = "12",
pages = "4957",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

AU - Jacobsen, Henning

AU - Walendy-Gnirß, Kerstin

AU - Tekin-Bubenheim, Nilgün

AU - Kouassi, Nancy Mounogou

AU - Ben-Batalla, Isabel

AU - Berenbrok, Nikolaus

AU - Wolff, Martin

AU - Dos Reis, Vinicius Pinho

AU - Zickler, Martin

AU - Scholl, Lucas

AU - Gries, Annette

AU - Jania, Hanna

AU - Kloetgen, Andreas

AU - Düsedau, Arne

AU - Pilnitz-Stolze, Gundula

AU - Jeridi, Aicha

AU - Yildirim, Ali Önder

AU - Fuchs, Helmut

AU - Gailus-Durner, Valerie

AU - Stoeger, Claudia

AU - de Angelis, Martin Hrabe

AU - Manuylova, Tatjana

AU - Klingel, Karin

AU - Culley, Fiona J

AU - Behrends, Jochen

AU - Loges, Sonja

AU - Schneider, Bianca

AU - Krauss-Etschmann, Susanne

AU - Openshaw, Peter

AU - Gabriel, Gülsah

N1 - © 2021. The Author(s).

PY - 2021/8/16

Y1 - 2021/8/16

N2 - Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.

AB - Influenza during pregnancy can affect the health of offspring in later life, among which neurocognitive disorders are among the best described. Here, we investigate whether maternal influenza infection has adverse effects on immune responses in offspring. We establish a two-hit mouse model to study the effect of maternal influenza A virus infection (first hit) on vulnerability of offspring to heterologous infections (second hit) in later life. Offspring born to influenza A virus infected mothers are stunted in growth and more vulnerable to heterologous infections (influenza B virus and MRSA) than those born to PBS- or poly(I:C)-treated mothers. Enhanced vulnerability to infection in neonates is associated with reduced haematopoetic development and immune responses. In particular, alveolar macrophages of offspring exposed to maternal influenza have reduced capacity to clear second hit pathogens. This impaired pathogen clearance is partially reversed by adoptive transfer of alveolar macrophages from healthy offspring born to uninfected dams. These findings suggest that maternal influenza infection may impair immune ontogeny and increase susceptibility to early life infections of offspring.

KW - Animals

KW - Animals, Newborn

KW - Bacterial Infections/immunology

KW - Disease Models, Animal

KW - Female

KW - Hematopoiesis

KW - Humans

KW - Influenza A virus/immunology

KW - Influenza, Human/immunology

KW - Lung/immunology

KW - Macrophages, Alveolar

KW - Mice

KW - Mice, Inbred C57BL

KW - Mothers

KW - Orthomyxoviridae Infections/virology

KW - Parturition

KW - Poly I-C

KW - Pregnancy

U2 - 10.1038/s41467-021-25220-3

DO - 10.1038/s41467-021-25220-3

M3 - SCORING: Journal article

C2 - 34400653

VL - 12

SP - 4957

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -