Oestradiol synthesized by female neurons generates sex differences in neuritogenesis
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Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. / Ruiz-Palmero, Isabel; Ortiz-Rodriguez, Ana; Melcangi, Roberto Cosimo; Caruso, Donatella; Garcia-Segura, Luis M; Rune, Gabriele M; Arevalo, Maria-Angeles.
In: SCI REP-UK, Vol. 6, 24.08.2016, p. 31891.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Oestradiol synthesized by female neurons generates sex differences in neuritogenesis
AU - Ruiz-Palmero, Isabel
AU - Ortiz-Rodriguez, Ana
AU - Melcangi, Roberto Cosimo
AU - Caruso, Donatella
AU - Garcia-Segura, Luis M
AU - Rune, Gabriele M
AU - Arevalo, Maria-Angeles
PY - 2016/8/24
Y1 - 2016/8/24
N2 - Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenesis than males. Exogenous application of testosterone or its metabolite dihydrotestosterone increases Neurogenin 3 expression and promotes neuritogenesis in males, but reduces these parameters in females. Together our data indicate that gonadal-independent oestradiol synthesis by female neurons participates in the generation of sex differences in hippocampal neuronal development.
AB - Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenesis than males. Exogenous application of testosterone or its metabolite dihydrotestosterone increases Neurogenin 3 expression and promotes neuritogenesis in males, but reduces these parameters in females. Together our data indicate that gonadal-independent oestradiol synthesis by female neurons participates in the generation of sex differences in hippocampal neuronal development.
KW - Journal Article
U2 - 10.1038/srep31891
DO - 10.1038/srep31891
M3 - SCORING: Journal article
C2 - 27553191
VL - 6
SP - 31891
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
ER -