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Oestradiol synthesized by female neurons generates sex differences in neuritogenesis

Standard

Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. / Ruiz-Palmero, Isabel; Ortiz-Rodriguez, Ana; Melcangi, Roberto Cosimo; Caruso, Donatella; Garcia-Segura, Luis M; Rune, Gabriele M; Arevalo, Maria-Angeles.

in: SCI REP-UK, Jahrgang 6, 24.08.2016, S. 31891.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ruiz-Palmero, I, Ortiz-Rodriguez, A, Melcangi, RC, Caruso, D, Garcia-Segura, LM, Rune, GM & Arevalo, M-A 2016, 'Oestradiol synthesized by female neurons generates sex differences in neuritogenesis', SCI REP-UK, Jg. 6, S. 31891. https://doi.org/10.1038/srep31891

APA

Ruiz-Palmero, I., Ortiz-Rodriguez, A., Melcangi, R. C., Caruso, D., Garcia-Segura, L. M., Rune, G. M., & Arevalo, M-A. (2016). Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. SCI REP-UK, 6, 31891. https://doi.org/10.1038/srep31891

Vancouver

Ruiz-Palmero I, Ortiz-Rodriguez A, Melcangi RC, Caruso D, Garcia-Segura LM, Rune GM et al. Oestradiol synthesized by female neurons generates sex differences in neuritogenesis. SCI REP-UK. 2016 Aug 24;6:31891. https://doi.org/10.1038/srep31891

Bibtex

@article{e274c55b094540d8939c88b763fad3c2,
title = "Oestradiol synthesized by female neurons generates sex differences in neuritogenesis",
abstract = "Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenesis than males. Exogenous application of testosterone or its metabolite dihydrotestosterone increases Neurogenin 3 expression and promotes neuritogenesis in males, but reduces these parameters in females. Together our data indicate that gonadal-independent oestradiol synthesis by female neurons participates in the generation of sex differences in hippocampal neuronal development.",
keywords = "Journal Article",
author = "Isabel Ruiz-Palmero and Ana Ortiz-Rodriguez and Melcangi, {Roberto Cosimo} and Donatella Caruso and Garcia-Segura, {Luis M} and Rune, {Gabriele M} and Maria-Angeles Arevalo",
year = "2016",
month = aug,
day = "24",
doi = "10.1038/srep31891",
language = "English",
volume = "6",
pages = "31891",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Oestradiol synthesized by female neurons generates sex differences in neuritogenesis

AU - Ruiz-Palmero, Isabel

AU - Ortiz-Rodriguez, Ana

AU - Melcangi, Roberto Cosimo

AU - Caruso, Donatella

AU - Garcia-Segura, Luis M

AU - Rune, Gabriele M

AU - Arevalo, Maria-Angeles

PY - 2016/8/24

Y1 - 2016/8/24

N2 - Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenesis than males. Exogenous application of testosterone or its metabolite dihydrotestosterone increases Neurogenin 3 expression and promotes neuritogenesis in males, but reduces these parameters in females. Together our data indicate that gonadal-independent oestradiol synthesis by female neurons participates in the generation of sex differences in hippocampal neuronal development.

AB - Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenesis than males. Exogenous application of testosterone or its metabolite dihydrotestosterone increases Neurogenin 3 expression and promotes neuritogenesis in males, but reduces these parameters in females. Together our data indicate that gonadal-independent oestradiol synthesis by female neurons participates in the generation of sex differences in hippocampal neuronal development.

KW - Journal Article

U2 - 10.1038/srep31891

DO - 10.1038/srep31891

M3 - SCORING: Journal article

C2 - 27553191

VL - 6

SP - 31891

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -