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Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs

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Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. / Pacheco-Fernandez, Natalia; Pakdel, Mehrshad; Blank, Birgit; Sanchez-Gonzalez, Ismael; Weber, Kathrin; Tran, Mai Ly; Hecht, Tobias Karl-Heinz; Gautsch, Renate; Beck, Gisela; Perez, Franck; Hausser, Angelika; Linder, Stefan; von Blume, Julia.

In: J CELL BIOL, Vol. 219, No. 8, 01.06.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pacheco-Fernandez, N, Pakdel, M, Blank, B, Sanchez-Gonzalez, I, Weber, K, Tran, ML, Hecht, TK-H, Gautsch, R, Beck, G, Perez, F, Hausser, A, Linder, S & von Blume, J 2020, 'Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs', J CELL BIOL, vol. 219, no. 8. https://doi.org/10.1083/jcb.201907058

APA

Pacheco-Fernandez, N., Pakdel, M., Blank, B., Sanchez-Gonzalez, I., Weber, K., Tran, M. L., Hecht, T. K-H., Gautsch, R., Beck, G., Perez, F., Hausser, A., Linder, S., & von Blume, J. (2020). Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. J CELL BIOL, 219(8). https://doi.org/10.1083/jcb.201907058

Vancouver

Pacheco-Fernandez N, Pakdel M, Blank B, Sanchez-Gonzalez I, Weber K, Tran ML et al. Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs. J CELL BIOL. 2020 Jun 1;219(8). https://doi.org/10.1083/jcb.201907058

Bibtex

@article{84fda8a83c904b31a726171f6ea0ee7c,
title = "Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs",
abstract = "Matrix metalloproteinases (MMPs) degrade several ECM components and are crucial modulators of cell invasion and tissue organization. Although much has been reported about their function in remodeling ECM in health and disease, their trafficking across the Golgi apparatus remains poorly understood. Here we report that the cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the Golgi apparatus. This process is Ca2+-dependent and is required for invasive MDA-MB-231 cell migration as well as for gelatin degradation in primary human macrophages. Our findings emphasize the importance of NUCB1 as an essential component of MMP transport and its overall impact on ECM remodeling.",
author = "Natalia Pacheco-Fernandez and Mehrshad Pakdel and Birgit Blank and Ismael Sanchez-Gonzalez and Kathrin Weber and Tran, {Mai Ly} and Hecht, {Tobias Karl-Heinz} and Renate Gautsch and Gisela Beck and Franck Perez and Angelika Hausser and Stefan Linder and {von Blume}, Julia",
note = "{\textcopyright} 2020 Pacheco-Fernandez et al.",
year = "2020",
month = jun,
day = "1",
doi = "10.1083/jcb.201907058",
language = "English",
volume = "219",
journal = "J CELL BIOL",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs

AU - Pacheco-Fernandez, Natalia

AU - Pakdel, Mehrshad

AU - Blank, Birgit

AU - Sanchez-Gonzalez, Ismael

AU - Weber, Kathrin

AU - Tran, Mai Ly

AU - Hecht, Tobias Karl-Heinz

AU - Gautsch, Renate

AU - Beck, Gisela

AU - Perez, Franck

AU - Hausser, Angelika

AU - Linder, Stefan

AU - von Blume, Julia

N1 - © 2020 Pacheco-Fernandez et al.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Matrix metalloproteinases (MMPs) degrade several ECM components and are crucial modulators of cell invasion and tissue organization. Although much has been reported about their function in remodeling ECM in health and disease, their trafficking across the Golgi apparatus remains poorly understood. Here we report that the cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the Golgi apparatus. This process is Ca2+-dependent and is required for invasive MDA-MB-231 cell migration as well as for gelatin degradation in primary human macrophages. Our findings emphasize the importance of NUCB1 as an essential component of MMP transport and its overall impact on ECM remodeling.

AB - Matrix metalloproteinases (MMPs) degrade several ECM components and are crucial modulators of cell invasion and tissue organization. Although much has been reported about their function in remodeling ECM in health and disease, their trafficking across the Golgi apparatus remains poorly understood. Here we report that the cis-Golgi protein nucleobindin-1 (NUCB1) is critical for MMP2 and MT1-MMP trafficking along the Golgi apparatus. This process is Ca2+-dependent and is required for invasive MDA-MB-231 cell migration as well as for gelatin degradation in primary human macrophages. Our findings emphasize the importance of NUCB1 as an essential component of MMP transport and its overall impact on ECM remodeling.

U2 - 10.1083/jcb.201907058

DO - 10.1083/jcb.201907058

M3 - SCORING: Journal article

C2 - 32479594

VL - 219

JO - J CELL BIOL

JF - J CELL BIOL

SN - 0021-9525

IS - 8

ER -