Novel functions of the anion exchanger AE4 (SLC4A9)

Helga Vitzthum; Catherine Meyer-Schwesinger; Heimo Ehmke

doi:10.1007/s00424-023-02899-5

Novel functions of the anion exchanger AE4 (SLC4A9)

Standard

Novel functions of the anion exchanger AE4 (SLC4A9). / Vitzthum, Helga ; Meyer-Schwesinger, Catherine; Ehmke, Heimo.

In: PFLUG ARCH EUR J PHY, Vol. 476, No. 4, 04.2024, p. 555-564.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Vitzthum, H , Meyer-Schwesinger, C & Ehmke, H 2024, 'Novel functions of the anion exchanger AE4 (SLC4A9)', PFLUG ARCH EUR J PHY, vol. 476, no. 4, pp. 555-564. https://doi.org/10.1007/s00424-023-02899-5

APA

Vitzthum, H., Meyer-Schwesinger, C., & Ehmke, H. (2024). Novel functions of the anion exchanger AE4 (SLC4A9). PFLUG ARCH EUR J PHY, 476(4), 555-564. https://doi.org/10.1007/s00424-023-02899-5

Vancouver

Vitzthum H , Meyer-Schwesinger C, Ehmke H. Novel functions of the anion exchanger AE4 (SLC4A9). PFLUG ARCH EUR J PHY. 2024 Apr;476(4):555-564. https://doi.org/10.1007/s00424-023-02899-5

Bibtex

@article{e7e87f634ead4c6c91481ae3703bf20e,

title = "Novel functions of the anion exchanger AE4 (SLC4A9)",

abstract = "The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells accomplish urinary base (HCO3-) secretion. β-intercalated cells regulate the acid base status through modulation of the apical Cl-/HCO3- exchanger pendrin (SLC26A4) activity. In this review, we summarize and discuss our current knowledge of the physiological role of the renal transporter AE4 (SLC4A9). The AE4, as cation-dependent Cl-/HCO3- exchanger, is exclusively expressed in the basolateral membrane of β-intercalated cells and is essential for the sensing of metabolic acid-base disturbances in mice, but not for renal sodium reabsorption and plasma volume control. Potential intracellular signaling pathways are discussed that might link basolateral acid-base sensing through the AE4 to apical pendrin activity.",

keywords = "Animals, Mice, Chloride-Bicarbonate Antiporters/metabolism, Kidney/metabolism, Kidney Tubules, Collecting/metabolism",

author = "Helga Vitzthum and Catherine Meyer-Schwesinger and Heimo Ehmke",

note = "{\textcopyright} 2024. The Author(s).",

year = "2024",

month = apr,

doi = "10.1007/s00424-023-02899-5",

language = "English",

volume = "476",

pages = "555--564",

journal = "PFLUG ARCH EUR J PHY",

issn = "0031-6768",

publisher = "Springer",

number = "4",

}

RIS

TY - JOUR

T1 - Novel functions of the anion exchanger AE4 (SLC4A9)

AU - Vitzthum, Helga

AU - Meyer-Schwesinger, Catherine

AU - Ehmke, Heimo

PY - 2024/4

Y1 - 2024/4

N2 - The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells accomplish urinary base (HCO3-) secretion. β-intercalated cells regulate the acid base status through modulation of the apical Cl-/HCO3- exchanger pendrin (SLC26A4) activity. In this review, we summarize and discuss our current knowledge of the physiological role of the renal transporter AE4 (SLC4A9). The AE4, as cation-dependent Cl-/HCO3- exchanger, is exclusively expressed in the basolateral membrane of β-intercalated cells and is essential for the sensing of metabolic acid-base disturbances in mice, but not for renal sodium reabsorption and plasma volume control. Potential intracellular signaling pathways are discussed that might link basolateral acid-base sensing through the AE4 to apical pendrin activity.

AB - The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells accomplish urinary base (HCO3-) secretion. β-intercalated cells regulate the acid base status through modulation of the apical Cl-/HCO3- exchanger pendrin (SLC26A4) activity. In this review, we summarize and discuss our current knowledge of the physiological role of the renal transporter AE4 (SLC4A9). The AE4, as cation-dependent Cl-/HCO3- exchanger, is exclusively expressed in the basolateral membrane of β-intercalated cells and is essential for the sensing of metabolic acid-base disturbances in mice, but not for renal sodium reabsorption and plasma volume control. Potential intracellular signaling pathways are discussed that might link basolateral acid-base sensing through the AE4 to apical pendrin activity.

KW - Animals

KW - Mice

KW - Chloride-Bicarbonate Antiporters/metabolism

KW - Kidney/metabolism

KW - Kidney Tubules, Collecting/metabolism

U2 - 10.1007/s00424-023-02899-5

DO - 10.1007/s00424-023-02899-5

M3 - SCORING: Review article

C2 - 38195948

VL - 476

SP - 555

EP - 564

JO - PFLUG ARCH EUR J PHY

JF - PFLUG ARCH EUR J PHY

SN - 0031-6768

IS - 4

ER -