Novel functions of the anion exchanger AE4 (SLC4A9)
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Novel functions of the anion exchanger AE4 (SLC4A9). / Vitzthum, Helga; Meyer-Schwesinger, Catherine; Ehmke, Heimo.
in: PFLUG ARCH EUR J PHY, Jahrgang 476, Nr. 4, 04.2024, S. 555-564.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Novel functions of the anion exchanger AE4 (SLC4A9)
AU - Vitzthum, Helga
AU - Meyer-Schwesinger, Catherine
AU - Ehmke, Heimo
N1 - © 2024. The Author(s).
PY - 2024/4
Y1 - 2024/4
N2 - The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells accomplish urinary base (HCO3-) secretion. β-intercalated cells regulate the acid base status through modulation of the apical Cl-/HCO3- exchanger pendrin (SLC26A4) activity. In this review, we summarize and discuss our current knowledge of the physiological role of the renal transporter AE4 (SLC4A9). The AE4, as cation-dependent Cl-/HCO3- exchanger, is exclusively expressed in the basolateral membrane of β-intercalated cells and is essential for the sensing of metabolic acid-base disturbances in mice, but not for renal sodium reabsorption and plasma volume control. Potential intracellular signaling pathways are discussed that might link basolateral acid-base sensing through the AE4 to apical pendrin activity.
AB - The kidney plays a crucial role in acid-base homeostasis. In the distal nephron, α-intercalated cells contribute to urinary acid (H+) secretion and β-intercalated cells accomplish urinary base (HCO3-) secretion. β-intercalated cells regulate the acid base status through modulation of the apical Cl-/HCO3- exchanger pendrin (SLC26A4) activity. In this review, we summarize and discuss our current knowledge of the physiological role of the renal transporter AE4 (SLC4A9). The AE4, as cation-dependent Cl-/HCO3- exchanger, is exclusively expressed in the basolateral membrane of β-intercalated cells and is essential for the sensing of metabolic acid-base disturbances in mice, but not for renal sodium reabsorption and plasma volume control. Potential intracellular signaling pathways are discussed that might link basolateral acid-base sensing through the AE4 to apical pendrin activity.
KW - Animals
KW - Mice
KW - Chloride-Bicarbonate Antiporters/metabolism
KW - Kidney/metabolism
KW - Kidney Tubules, Collecting/metabolism
U2 - 10.1007/s00424-023-02899-5
DO - 10.1007/s00424-023-02899-5
M3 - SCORING: Review article
C2 - 38195948
VL - 476
SP - 555
EP - 564
JO - PFLUG ARCH EUR J PHY
JF - PFLUG ARCH EUR J PHY
SN - 0031-6768
IS - 4
ER -