Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
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Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis. / Scheja, Ludger; Heeren, Joerg.
Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets. ed. / Arnold von Eckardstein; Christoph J. Binder. Vol. 270 1. ed. Cham : Springer, 2022. p. 289-310 (Handbook of Experimental Pharmacology; Vol. 270).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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TY - CHAP
T1 - Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
AU - Scheja, Ludger
AU - Heeren, Joerg
PY - 2022
Y1 - 2022
N2 - Adipose tissue as a major organ of lipid and lipoprotein metabolism has a major impact on metabolic homeostasis and thus influences the development of atherosclerosis and related cardiometabolic diseases. Unhealthy adipose tissue, which is often associated with obesity and systemic insulin resistance, promotes the development of diabetic dyslipidemia and can negatively affect vascular tissue homeostasis by secreting pro-inflammatory peptides and lipids. Conversely, paracrine and endocrine factors that are released from healthy adipose tissue can preserve metabolic balance and a functional vasculature. In this chapter, we describe adipose tissue types relevant for atherosclerosis and address the question how lipid metabolism as well as regulatory molecules produced in these fat depots can be targeted to counteract atherogenic processes in the vessel wall and improve plasma lipids. We discuss the role of adipose tissues in the action of approved drugs with anti-atherogenic activity. In addition, we present potential novel targets and therapeutic approaches aimed at increasing lipoprotein disposal in adipose tissue, boosting the activity of heat-producing (thermogenic) adipocytes, reducing adipose tissue inflammation, and improving or replacing beneficial hormones released from adipose tissues. Furthermore, we describe the future potential of innovative drug delivery technologies.
AB - Adipose tissue as a major organ of lipid and lipoprotein metabolism has a major impact on metabolic homeostasis and thus influences the development of atherosclerosis and related cardiometabolic diseases. Unhealthy adipose tissue, which is often associated with obesity and systemic insulin resistance, promotes the development of diabetic dyslipidemia and can negatively affect vascular tissue homeostasis by secreting pro-inflammatory peptides and lipids. Conversely, paracrine and endocrine factors that are released from healthy adipose tissue can preserve metabolic balance and a functional vasculature. In this chapter, we describe adipose tissue types relevant for atherosclerosis and address the question how lipid metabolism as well as regulatory molecules produced in these fat depots can be targeted to counteract atherogenic processes in the vessel wall and improve plasma lipids. We discuss the role of adipose tissues in the action of approved drugs with anti-atherogenic activity. In addition, we present potential novel targets and therapeutic approaches aimed at increasing lipoprotein disposal in adipose tissue, boosting the activity of heat-producing (thermogenic) adipocytes, reducing adipose tissue inflammation, and improving or replacing beneficial hormones released from adipose tissues. Furthermore, we describe the future potential of innovative drug delivery technologies.
U2 - 10.1007/164_2020_363
DO - 10.1007/164_2020_363
M3 - SCORING: Contribution to collected editions/anthologies
C2 - 33373032
SN - 978-3-030-86075-2
VL - 270
T3 - Handbook of Experimental Pharmacology
SP - 289
EP - 310
BT - Prevention and Treatment of Atherosclerosis
A2 - von Eckardstein, Arnold
A2 - Binder, Christoph J.
PB - Springer
CY - Cham
ER -
