Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery
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Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. / Hoppe, Steffi; von Loeffelholz, Christian; Lock, Johan F; Doecke, Stephanie; Sinn, Bruno V; Rieger, Anja; Malinowski, Maciej; Pfeiffer, Andreas F H; Neuhaus, Peter; Stockmann, Martin.
In: J INVEST SURG, Vol. 28, No. 1, 02.2015, p. 24-31.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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T1 - Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery
AU - Hoppe, Steffi
AU - von Loeffelholz, Christian
AU - Lock, Johan F
AU - Doecke, Stephanie
AU - Sinn, Bruno V
AU - Rieger, Anja
AU - Malinowski, Maciej
AU - Pfeiffer, Andreas F H
AU - Neuhaus, Peter
AU - Stockmann, Martin
PY - 2015/2
Y1 - 2015/2
N2 - BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery.METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.
AB - BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery.METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.
KW - Adenocarcinoma
KW - Adult
KW - Aged
KW - Anthropometry
KW - Carcinoma, Hepatocellular
KW - Cholangiocarcinoma
KW - Colorectal Neoplasms
KW - Fatty Liver
KW - Female
KW - Follow-Up Studies
KW - Hepatectomy
KW - Humans
KW - Length of Stay
KW - Liver Function Tests
KW - Liver Neoplasms
KW - Liver Regeneration
KW - Male
KW - Middle Aged
KW - Non-alcoholic Fatty Liver Disease
KW - Obesity
KW - Pilot Projects
KW - Postoperative Period
KW - Prospective Studies
KW - Recovery of Function
KW - Severity of Illness Index
KW - Single-Blind Method
U2 - 10.3109/08941939.2014.971206
DO - 10.3109/08941939.2014.971206
M3 - SCORING: Journal article
C2 - 25394215
VL - 28
SP - 24
EP - 31
JO - J INVEST SURG
JF - J INVEST SURG
SN - 0894-1939
IS - 1
ER -