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Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery

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Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. / Hoppe, Steffi; von Loeffelholz, Christian; Lock, Johan F; Doecke, Stephanie; Sinn, Bruno V; Rieger, Anja; Malinowski, Maciej; Pfeiffer, Andreas F H; Neuhaus, Peter; Stockmann, Martin.

in: J INVEST SURG, Jahrgang 28, Nr. 1, 02.2015, S. 24-31.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Hoppe, S, von Loeffelholz, C, Lock, JF, Doecke, S, Sinn, BV, Rieger, A, Malinowski, M, Pfeiffer, AFH, Neuhaus, P & Stockmann, M 2015, 'Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery', J INVEST SURG, Jg. 28, Nr. 1, S. 24-31. https://doi.org/10.3109/08941939.2014.971206

APA

Hoppe, S., von Loeffelholz, C., Lock, J. F., Doecke, S., Sinn, B. V., Rieger, A., Malinowski, M., Pfeiffer, A. F. H., Neuhaus, P., & Stockmann, M. (2015). Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. J INVEST SURG, 28(1), 24-31. https://doi.org/10.3109/08941939.2014.971206

Vancouver

Hoppe S, von Loeffelholz C, Lock JF, Doecke S, Sinn BV, Rieger A et al. Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery. J INVEST SURG. 2015 Feb;28(1):24-31. https://doi.org/10.3109/08941939.2014.971206

Bibtex

@article{05e4ef676d5346f09019ef0a43517c2a,
title = "Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery",
abstract = "BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery.METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.",
keywords = "Adenocarcinoma, Adult, Aged, Anthropometry, Carcinoma, Hepatocellular, Cholangiocarcinoma, Colorectal Neoplasms, Fatty Liver, Female, Follow-Up Studies, Hepatectomy, Humans, Length of Stay, Liver Function Tests, Liver Neoplasms, Liver Regeneration, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Obesity, Pilot Projects, Postoperative Period, Prospective Studies, Recovery of Function, Severity of Illness Index, Single-Blind Method",
author = "Steffi Hoppe and {von Loeffelholz}, Christian and Lock, {Johan F} and Stephanie Doecke and Sinn, {Bruno V} and Anja Rieger and Maciej Malinowski and Pfeiffer, {Andreas F H} and Peter Neuhaus and Martin Stockmann",
year = "2015",
month = feb,
doi = "10.3109/08941939.2014.971206",
language = "English",
volume = "28",
pages = "24--31",
journal = "J INVEST SURG",
issn = "0894-1939",
publisher = "informa healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Nonalcoholic steatohepatits and liver steatosis modify partial hepatectomy recovery

AU - Hoppe, Steffi

AU - von Loeffelholz, Christian

AU - Lock, Johan F

AU - Doecke, Stephanie

AU - Sinn, Bruno V

AU - Rieger, Anja

AU - Malinowski, Maciej

AU - Pfeiffer, Andreas F H

AU - Neuhaus, Peter

AU - Stockmann, Martin

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery.METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.

AB - BACKGROUND: The impact of nonalcoholic fatty liver disease (NAFLD) comprising simple steatosis (NAFL) and steatohepatitis (NASH) on liver recovery after partial hepatectomy has not been evaluated. This pilot study investigated whether there is an effect of proven NAFLD on liver recovery.METHODS: Thirty-one patients elected for partial hepatectomy were characterized and included into a prospective study. Liver samples were staged according to the NAFLD activity score. Liver function was measured by using the LiMAx method on postoperative days (POD) 1, 3, 5, and 10.RESULTS: Nineteen patients were identified to suffer from NAFLD (NAFL, n = 11; NASH, n = 8). In NAFL, preoperative liver function (p = .48) and hepatic recovery on POD 1, 3, and 5 was comparable to controls (p > .05, respectively), while it was impaired on POD 10 (p = .022). NASH patients had preoperative enzymatic function comparable to controls (p = .10), but there was a trend to reduced levels on POD 1 (p = .082) and 5 (p = .062), which became significant on POD 10 (p = .003).CONCLUSION: This study suggests that NAFLD impairs functional recovery assessed by LiMAx after partial hepatectomy.

KW - Adenocarcinoma

KW - Adult

KW - Aged

KW - Anthropometry

KW - Carcinoma, Hepatocellular

KW - Cholangiocarcinoma

KW - Colorectal Neoplasms

KW - Fatty Liver

KW - Female

KW - Follow-Up Studies

KW - Hepatectomy

KW - Humans

KW - Length of Stay

KW - Liver Function Tests

KW - Liver Neoplasms

KW - Liver Regeneration

KW - Male

KW - Middle Aged

KW - Non-alcoholic Fatty Liver Disease

KW - Obesity

KW - Pilot Projects

KW - Postoperative Period

KW - Prospective Studies

KW - Recovery of Function

KW - Severity of Illness Index

KW - Single-Blind Method

U2 - 10.3109/08941939.2014.971206

DO - 10.3109/08941939.2014.971206

M3 - SCORING: Journal article

C2 - 25394215

VL - 28

SP - 24

EP - 31

JO - J INVEST SURG

JF - J INVEST SURG

SN - 0894-1939

IS - 1

ER -