No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations
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No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. / Deindl, Philipp; Peri-Jerkan, Silvija; Deichmann, Klaus; Niggemann, Bodo; Lau, Susanne; Sommerfeld, Christine; Sengler, Claudia; Müller, Sebastian; Wahn, Ulrich; Nickel, Renate; Heinzmann, Andrea; German Multicenter Atopy Study Group.
In: PEDIAT ALLERG IMM-UK, Vol. 16, No. 1, 01.02.2005, p. 40-2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations
AU - Deindl, Philipp
AU - Peri-Jerkan, Silvija
AU - Deichmann, Klaus
AU - Niggemann, Bodo
AU - Lau, Susanne
AU - Sommerfeld, Christine
AU - Sengler, Claudia
AU - Müller, Sebastian
AU - Wahn, Ulrich
AU - Nickel, Renate
AU - Heinzmann, Andrea
AU - German Multicenter Atopy Study Group
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.
AB - Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.
KW - Adolescent
KW - Asthma
KW - Bronchial Hyperreactivity
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Follow-Up Studies
KW - Germany
KW - Histamine
KW - Histamine N-Methyltransferase
KW - Humans
KW - Polymorphism, Single Nucleotide
U2 - 10.1111/j.1399-3038.2005.00218.x
DO - 10.1111/j.1399-3038.2005.00218.x
M3 - SCORING: Journal article
C2 - 15693910
VL - 16
SP - 40
EP - 42
JO - PEDIAT ALLERG IMM-UK
JF - PEDIAT ALLERG IMM-UK
SN - 0905-6157
IS - 1
ER -