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No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations

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No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. / Deindl, Philipp; Peri-Jerkan, Silvija; Deichmann, Klaus; Niggemann, Bodo; Lau, Susanne; Sommerfeld, Christine; Sengler, Claudia; Müller, Sebastian; Wahn, Ulrich; Nickel, Renate; Heinzmann, Andrea; German Multicenter Atopy Study Group.

in: PEDIAT ALLERG IMM-UK, Jahrgang 16, Nr. 1, 01.02.2005, S. 40-2.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Deindl, P, Peri-Jerkan, S, Deichmann, K, Niggemann, B, Lau, S, Sommerfeld, C, Sengler, C, Müller, S, Wahn, U, Nickel, R, Heinzmann, A & German Multicenter Atopy Study Group 2005, 'No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations', PEDIAT ALLERG IMM-UK, Jg. 16, Nr. 1, S. 40-2. https://doi.org/10.1111/j.1399-3038.2005.00218.x

APA

Deindl, P., Peri-Jerkan, S., Deichmann, K., Niggemann, B., Lau, S., Sommerfeld, C., Sengler, C., Müller, S., Wahn, U., Nickel, R., Heinzmann, A., & German Multicenter Atopy Study Group (2005). No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. PEDIAT ALLERG IMM-UK, 16(1), 40-2. https://doi.org/10.1111/j.1399-3038.2005.00218.x

Vancouver

Deindl P, Peri-Jerkan S, Deichmann K, Niggemann B, Lau S, Sommerfeld C et al. No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. PEDIAT ALLERG IMM-UK. 2005 Feb 1;16(1):40-2. https://doi.org/10.1111/j.1399-3038.2005.00218.x

Bibtex

@article{5e849f062d9b4baa87ce8d6ccd053e91,
title = "No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations",
abstract = "Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.",
keywords = "Adolescent, Asthma, Bronchial Hyperreactivity, Child, Child, Preschool, Cohort Studies, Follow-Up Studies, Germany, Histamine, Histamine N-Methyltransferase, Humans, Polymorphism, Single Nucleotide",
author = "Philipp Deindl and Silvija Peri-Jerkan and Klaus Deichmann and Bodo Niggemann and Susanne Lau and Christine Sommerfeld and Claudia Sengler and Sebastian M{\"u}ller and Ulrich Wahn and Renate Nickel and Andrea Heinzmann and {German Multicenter Atopy Study Group}",
year = "2005",
month = feb,
day = "1",
doi = "10.1111/j.1399-3038.2005.00218.x",
language = "English",
volume = "16",
pages = "40--2",
journal = "PEDIAT ALLERG IMM-UK",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "1",

}

RIS

TY - JOUR

T1 - No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations

AU - Deindl, Philipp

AU - Peri-Jerkan, Silvija

AU - Deichmann, Klaus

AU - Niggemann, Bodo

AU - Lau, Susanne

AU - Sommerfeld, Christine

AU - Sengler, Claudia

AU - Müller, Sebastian

AU - Wahn, Ulrich

AU - Nickel, Renate

AU - Heinzmann, Andrea

AU - German Multicenter Atopy Study Group

PY - 2005/2/1

Y1 - 2005/2/1

N2 - Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.

AB - Histamine plays an important role in the allergic inflammation. Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. A common functional single nucleotide polymorphism (SNP) within the HNMT gene (C314T) was recently related to asthma. We tested this SNP for associations with asthma and asthma associated traits in two German pediatric populations (1. MAS-cohort, n=888, 85 children with asthma; 2. asthmatic children from Freiburg, n=176). Non-asthmatic (n=515) and non-atopic (n=211) children from the MAS-cohort were used as controls. For genotyping melting curve analyses (Light Cycler System) were applied. In contrast to a previous study, no association of the HNMT 314T allele with asthma, bronchial hyperresponsiveness (BHR) or other asthma related phenotypes could be observed in either study population. We conclude that this SNP might not play a major role in the pathogenesis of asthma or BHR in German children.

KW - Adolescent

KW - Asthma

KW - Bronchial Hyperreactivity

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Follow-Up Studies

KW - Germany

KW - Histamine

KW - Histamine N-Methyltransferase

KW - Humans

KW - Polymorphism, Single Nucleotide

U2 - 10.1111/j.1399-3038.2005.00218.x

DO - 10.1111/j.1399-3038.2005.00218.x

M3 - SCORING: Journal article

C2 - 15693910

VL - 16

SP - 40

EP - 42

JO - PEDIAT ALLERG IMM-UK

JF - PEDIAT ALLERG IMM-UK

SN - 0905-6157

IS - 1

ER -