No acute suppression of cerebrospinal fluid corticotropin-releasing hormone in man by cortisol administration

Michael Kellner; Cornelie Salzwedel; Viola Wortmann; Tatiana Urbanowicz; Kai Boelmans; Alexander Yassouridis; Günter K Stalla; Klaus Wiedemann

doi:10.1016/j.psychres.2013.07.003

No acute suppression of cerebrospinal fluid corticotropin-releasing hormone in man by cortisol administration

Michael Kellner
Cornelie Salzwedel
Viola Wortmann
Tatiana Urbanowicz
Kai Boelmans
Alexander Yassouridis
Günter K Stalla
Klaus Wiedemann

Related Research units

Department of Psychiatry and Psychotherapy
Department of Anesthesiology

Abstract

Corticotropin-releasing hormone (CRH) in cerebrospinal fluid (CSF) is regarded as index of brain endocrine and behavioral functioning. We investigated the acute effects of intravenous cortisol (100mg) vs. placebo on serial CSF CRH in ten healthy men. CSF CRH concentrations were not significantly suppressed by cortisol within 3h. The origin and regulation of CSF CRH need further research.

Bibliographical data

Original language	English
DOIs	https://doi.org/10.1016/j.psychres.2013.07.003
Publication status	Published - 15.12.2013

PubMed	23896353