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Night work and breast cancer estrogen receptor status--results from the German GENICA study

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Night work and breast cancer estrogen receptor status--results from the German GENICA study. / Rabstein, Sylvia; Harth, Volker; Pesch, Beate; Pallapies, Dirk; Lotz, Anne; Justenhoven, Christina; Baisch, Christian; Schiffermann, Markus; Haas, Susanne; Fischer, Hans-Peter; Heinze, Evelyn; Pierl, Christiane; Brauch, Hiltrud; Hamann, Ute; Ko, Yon; Brüning, Thomas; GENICA Consortium.

In: Scandinavian journal of work, environment & health, Vol. 39, No. 5, 01.09.2013, p. 448-55.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rabstein, S, Harth, V, Pesch, B, Pallapies, D, Lotz, A, Justenhoven, C, Baisch, C, Schiffermann, M, Haas, S, Fischer, H-P, Heinze, E, Pierl, C, Brauch, H, Hamann, U, Ko, Y, Brüning, T & GENICA Consortium 2013, 'Night work and breast cancer estrogen receptor status--results from the German GENICA study', Scandinavian journal of work, environment & health, vol. 39, no. 5, pp. 448-55. https://doi.org/10.5271/sjweh.3360

APA

Rabstein, S., Harth, V., Pesch, B., Pallapies, D., Lotz, A., Justenhoven, C., Baisch, C., Schiffermann, M., Haas, S., Fischer, H-P., Heinze, E., Pierl, C., Brauch, H., Hamann, U., Ko, Y., Brüning, T., & GENICA Consortium (2013). Night work and breast cancer estrogen receptor status--results from the German GENICA study. Scandinavian journal of work, environment & health, 39(5), 448-55. https://doi.org/10.5271/sjweh.3360

Vancouver

Rabstein S, Harth V, Pesch B, Pallapies D, Lotz A, Justenhoven C et al. Night work and breast cancer estrogen receptor status--results from the German GENICA study. Scandinavian journal of work, environment & health. 2013 Sep 1;39(5):448-55. https://doi.org/10.5271/sjweh.3360

Bibtex

@article{cbcc98ec6abe44588b62c0f74d703ca7,
title = "Night work and breast cancer estrogen receptor status--results from the German GENICA study",
abstract = "OBJECTIVES: The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.METHODS: GENICA (Gene-ENvironment Interaction and breast CAncer) is a population-based case-control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.RESULTS: ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were {"}ever employed{"} in shift work including night shifts for ≥ 1 year. In total, {"}ever shift work{"} and {"}ever night work{"} were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥ 20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22-18.36].CONCLUSIONS: Our case-control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms.",
keywords = "Aged, Aged, 80 and over, Breast Neoplasms, Case-Control Studies, Female, Germany, Humans, Middle Aged, Receptors, Estrogen, Work Schedule Tolerance",
author = "Sylvia Rabstein and Volker Harth and Beate Pesch and Dirk Pallapies and Anne Lotz and Christina Justenhoven and Christian Baisch and Markus Schiffermann and Susanne Haas and Hans-Peter Fischer and Evelyn Heinze and Christiane Pierl and Hiltrud Brauch and Ute Hamann and Yon Ko and Thomas Br{\"u}ning and {GENICA Consortium}",
year = "2013",
month = sep,
day = "1",
doi = "10.5271/sjweh.3360",
language = "English",
volume = "39",
pages = "448--55",
journal = "SCAND J WORK ENV HEA",
issn = "0355-3140",
publisher = "Finnish Institute of Occupational Health",
number = "5",

}

RIS

TY - JOUR

T1 - Night work and breast cancer estrogen receptor status--results from the German GENICA study

AU - Rabstein, Sylvia

AU - Harth, Volker

AU - Pesch, Beate

AU - Pallapies, Dirk

AU - Lotz, Anne

AU - Justenhoven, Christina

AU - Baisch, Christian

AU - Schiffermann, Markus

AU - Haas, Susanne

AU - Fischer, Hans-Peter

AU - Heinze, Evelyn

AU - Pierl, Christiane

AU - Brauch, Hiltrud

AU - Hamann, Ute

AU - Ko, Yon

AU - Brüning, Thomas

AU - GENICA Consortium

PY - 2013/9/1

Y1 - 2013/9/1

N2 - OBJECTIVES: The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.METHODS: GENICA (Gene-ENvironment Interaction and breast CAncer) is a population-based case-control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.RESULTS: ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were "ever employed" in shift work including night shifts for ≥ 1 year. In total, "ever shift work" and "ever night work" were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥ 20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22-18.36].CONCLUSIONS: Our case-control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms.

AB - OBJECTIVES: The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.METHODS: GENICA (Gene-ENvironment Interaction and breast CAncer) is a population-based case-control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.RESULTS: ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were "ever employed" in shift work including night shifts for ≥ 1 year. In total, "ever shift work" and "ever night work" were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥ 20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22-18.36].CONCLUSIONS: Our case-control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms.

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Female

KW - Germany

KW - Humans

KW - Middle Aged

KW - Receptors, Estrogen

KW - Work Schedule Tolerance

U2 - 10.5271/sjweh.3360

DO - 10.5271/sjweh.3360

M3 - SCORING: Journal article

C2 - 23543199

VL - 39

SP - 448

EP - 455

JO - SCAND J WORK ENV HEA

JF - SCAND J WORK ENV HEA

SN - 0355-3140

IS - 5

ER -