Night work and breast cancer estrogen receptor status--results from the German GENICA study
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Night work and breast cancer estrogen receptor status--results from the German GENICA study. / Rabstein, Sylvia; Harth, Volker; Pesch, Beate; Pallapies, Dirk; Lotz, Anne; Justenhoven, Christina; Baisch, Christian; Schiffermann, Markus; Haas, Susanne; Fischer, Hans-Peter; Heinze, Evelyn; Pierl, Christiane; Brauch, Hiltrud; Hamann, Ute; Ko, Yon; Brüning, Thomas; GENICA Consortium.
in: Scandinavian journal of work, environment & health, Jahrgang 39, Nr. 5, 01.09.2013, S. 448-55.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Night work and breast cancer estrogen receptor status--results from the German GENICA study
AU - Rabstein, Sylvia
AU - Harth, Volker
AU - Pesch, Beate
AU - Pallapies, Dirk
AU - Lotz, Anne
AU - Justenhoven, Christina
AU - Baisch, Christian
AU - Schiffermann, Markus
AU - Haas, Susanne
AU - Fischer, Hans-Peter
AU - Heinze, Evelyn
AU - Pierl, Christiane
AU - Brauch, Hiltrud
AU - Hamann, Ute
AU - Ko, Yon
AU - Brüning, Thomas
AU - GENICA Consortium
PY - 2013/9/1
Y1 - 2013/9/1
N2 - OBJECTIVES: The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.METHODS: GENICA (Gene-ENvironment Interaction and breast CAncer) is a population-based case-control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.RESULTS: ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were "ever employed" in shift work including night shifts for ≥ 1 year. In total, "ever shift work" and "ever night work" were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥ 20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22-18.36].CONCLUSIONS: Our case-control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms.
AB - OBJECTIVES: The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explored the association between shift work and breast cancer in subgroups of patients with ER-positive and -negative tumors.METHODS: GENICA (Gene-ENvironment Interaction and breast CAncer) is a population-based case-control study on breast cancer with detailed information on shift work from 857 breast cancer cases and 892 controls. ER status was assessed by immunohistochemical staining. Associations between night-shift work and ER-positive and -negative breast cancer were analyzed with conditional logistic regression models, adjusted for potential confounders.RESULTS: ER status was assessed for 827 cases and was positive in 653 and negative in 174 breast tumors. Overall, 49 cases and 54 controls were "ever employed" in shift work including night shifts for ≥ 1 year. In total, "ever shift work" and "ever night work" were not associated with an elevated risk of ER-positive or -negative breast tumors. Night work for ≥ 20 years was associated with a significantly elevated risk of ER-negative breast cancer [odds ratio (OR) 4.73, 95% confidence interval (95% CI) 1.22-18.36].CONCLUSIONS: Our case-control study suggests that long-term night-shift work is associated with an increased risk of ER-negative breast cancers. Further studies on histological subtypes and the analysis of other potentially relevant factors are crucial for discovering putative mechanisms.
KW - Aged
KW - Aged, 80 and over
KW - Breast Neoplasms
KW - Case-Control Studies
KW - Female
KW - Germany
KW - Humans
KW - Middle Aged
KW - Receptors, Estrogen
KW - Work Schedule Tolerance
U2 - 10.5271/sjweh.3360
DO - 10.5271/sjweh.3360
M3 - SCORING: Journal article
C2 - 23543199
VL - 39
SP - 448
EP - 455
JO - SCAND J WORK ENV HEA
JF - SCAND J WORK ENV HEA
SN - 0355-3140
IS - 5
ER -