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New susceptibility locus for coronary artery disease on chromosome 3q22.3

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New susceptibility locus for coronary artery disease on chromosome 3q22.3. / Erdmann, Jeanette; Grosshennig, Anika; Braund, Peter S; König, Inke R; Hengstenberg, Christian; Hall, Alistair S; Linsel-Nitschke, Patrick; Kathiresan, Sekar; Wright, Ben; Trégouët, David-Alexandre; Cambien, Francois; Bruse, Petra; Aherrahrou, Zouhair; Wagner, Arnika K; Stark, Klaus; Schwartz, Stephen M; Salomaa, Veikko; Elosua, Roberto; Melander, Olle; Voight, Benjamin F; O'Donnell, Christopher J; Peltonen, Leena; Siscovick, David S; Altshuler, David; Merlini, Piera Angelica; Peyvandi, Flora; Bernardinelli, Luisa; Ardissino, Diego; Schillert, Arne; Blankenberg, Stefan; Zeller, Tanja; Wild, Philipp; Schwarz, Daniel F; Tiret, Laurence; Perret, Claire; Schreiber, Stefan; El Mokhtari, Nour Eddine; Schäfer, Arne; März, Winfried; Renner, Wilfried; Bugert, Peter; Klüter, Harald; Schrezenmeir, Jürgen; Rubin, Diana; Ball, Stephen G; Balmforth, Anthony J; Wichmann, H-Erich; Meitinger, Thomas; Fischer, Marcus; Meisinger, Christa; Baumert, Jens; Peters, Annette; Ouwehand, Willem H; Deloukas, Panos; Thompson, John R; Ziegler, Andreas; Samani, Nilesh J; Schunkert, Heribert; Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group.

In: NAT GENET, Vol. 41, No. 3, 03.2009, p. 280-282.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Erdmann, J, Grosshennig, A, Braund, PS, König, IR, Hengstenberg, C, Hall, AS, Linsel-Nitschke, P, Kathiresan, S, Wright, B, Trégouët, D-A, Cambien, F, Bruse, P, Aherrahrou, Z, Wagner, AK, Stark, K, Schwartz, SM, Salomaa, V, Elosua, R, Melander, O, Voight, BF, O'Donnell, CJ, Peltonen, L, Siscovick, DS, Altshuler, D, Merlini, PA, Peyvandi, F, Bernardinelli, L, Ardissino, D, Schillert, A, Blankenberg, S, Zeller, T, Wild, P, Schwarz, DF, Tiret, L, Perret, C, Schreiber, S, El Mokhtari, NE, Schäfer, A, März, W, Renner, W, Bugert, P, Klüter, H, Schrezenmeir, J, Rubin, D, Ball, SG, Balmforth, AJ, Wichmann, H-E, Meitinger, T, Fischer, M, Meisinger, C, Baumert, J, Peters, A, Ouwehand, WH, Deloukas, P, Thompson, JR, Ziegler, A, Samani, NJ, Schunkert, H & Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group 2009, 'New susceptibility locus for coronary artery disease on chromosome 3q22.3', NAT GENET, vol. 41, no. 3, pp. 280-282. https://doi.org/10.1038/ng.307

APA

Erdmann, J., Grosshennig, A., Braund, P. S., König, I. R., Hengstenberg, C., Hall, A. S., Linsel-Nitschke, P., Kathiresan, S., Wright, B., Trégouët, D-A., Cambien, F., Bruse, P., Aherrahrou, Z., Wagner, A. K., Stark, K., Schwartz, S. M., Salomaa, V., Elosua, R., Melander, O., ... Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group (2009). New susceptibility locus for coronary artery disease on chromosome 3q22.3. NAT GENET, 41(3), 280-282. https://doi.org/10.1038/ng.307

Vancouver

Erdmann J, Grosshennig A, Braund PS, König IR, Hengstenberg C, Hall AS et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. NAT GENET. 2009 Mar;41(3):280-282. https://doi.org/10.1038/ng.307

Bibtex

@article{79ab4e29b5d34520b075608a63c2a40e,
title = "New susceptibility locus for coronary artery disease on chromosome 3q22.3",
abstract = "We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).",
keywords = "Case-Control Studies, Chromosomes, Human, Pair 3, Coronary Artery Disease/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Germany, Hepatocyte Nuclear Factor 1-alpha/genetics, Humans, Polymorphism, Single Nucleotide, Quantitative Trait Loci, ras Proteins/genetics",
author = "Jeanette Erdmann and Anika Grosshennig and Braund, {Peter S} and K{\"o}nig, {Inke R} and Christian Hengstenberg and Hall, {Alistair S} and Patrick Linsel-Nitschke and Sekar Kathiresan and Ben Wright and David-Alexandre Tr{\'e}gou{\"e}t and Francois Cambien and Petra Bruse and Zouhair Aherrahrou and Wagner, {Arnika K} and Klaus Stark and Schwartz, {Stephen M} and Veikko Salomaa and Roberto Elosua and Olle Melander and Voight, {Benjamin F} and O'Donnell, {Christopher J} and Leena Peltonen and Siscovick, {David S} and David Altshuler and Merlini, {Piera Angelica} and Flora Peyvandi and Luisa Bernardinelli and Diego Ardissino and Arne Schillert and Stefan Blankenberg and Tanja Zeller and Philipp Wild and Schwarz, {Daniel F} and Laurence Tiret and Claire Perret and Stefan Schreiber and {El Mokhtari}, {Nour Eddine} and Arne Sch{\"a}fer and Winfried M{\"a}rz and Wilfried Renner and Peter Bugert and Harald Kl{\"u}ter and J{\"u}rgen Schrezenmeir and Diana Rubin and Ball, {Stephen G} and Balmforth, {Anthony J} and H-Erich Wichmann and Thomas Meitinger and Marcus Fischer and Christa Meisinger and Jens Baumert and Annette Peters and Ouwehand, {Willem H} and Panos Deloukas and Thompson, {John R} and Andreas Ziegler and Samani, {Nilesh J} and Heribert Schunkert and {Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group}",
year = "2009",
month = mar,
doi = "10.1038/ng.307",
language = "English",
volume = "41",
pages = "280--282",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - New susceptibility locus for coronary artery disease on chromosome 3q22.3

AU - Erdmann, Jeanette

AU - Grosshennig, Anika

AU - Braund, Peter S

AU - König, Inke R

AU - Hengstenberg, Christian

AU - Hall, Alistair S

AU - Linsel-Nitschke, Patrick

AU - Kathiresan, Sekar

AU - Wright, Ben

AU - Trégouët, David-Alexandre

AU - Cambien, Francois

AU - Bruse, Petra

AU - Aherrahrou, Zouhair

AU - Wagner, Arnika K

AU - Stark, Klaus

AU - Schwartz, Stephen M

AU - Salomaa, Veikko

AU - Elosua, Roberto

AU - Melander, Olle

AU - Voight, Benjamin F

AU - O'Donnell, Christopher J

AU - Peltonen, Leena

AU - Siscovick, David S

AU - Altshuler, David

AU - Merlini, Piera Angelica

AU - Peyvandi, Flora

AU - Bernardinelli, Luisa

AU - Ardissino, Diego

AU - Schillert, Arne

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Wild, Philipp

AU - Schwarz, Daniel F

AU - Tiret, Laurence

AU - Perret, Claire

AU - Schreiber, Stefan

AU - El Mokhtari, Nour Eddine

AU - Schäfer, Arne

AU - März, Winfried

AU - Renner, Wilfried

AU - Bugert, Peter

AU - Klüter, Harald

AU - Schrezenmeir, Jürgen

AU - Rubin, Diana

AU - Ball, Stephen G

AU - Balmforth, Anthony J

AU - Wichmann, H-Erich

AU - Meitinger, Thomas

AU - Fischer, Marcus

AU - Meisinger, Christa

AU - Baumert, Jens

AU - Peters, Annette

AU - Ouwehand, Willem H

AU - Deloukas, Panos

AU - Thompson, John R

AU - Ziegler, Andreas

AU - Samani, Nilesh J

AU - Schunkert, Heribert

AU - Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group

PY - 2009/3

Y1 - 2009/3

N2 - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

AB - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

KW - Case-Control Studies

KW - Chromosomes, Human, Pair 3

KW - Coronary Artery Disease/genetics

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Germany

KW - Hepatocyte Nuclear Factor 1-alpha/genetics

KW - Humans

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - ras Proteins/genetics

U2 - 10.1038/ng.307

DO - 10.1038/ng.307

M3 - SCORING: Journal article

C2 - 19198612

VL - 41

SP - 280

EP - 282

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 3

ER -