New susceptibility locus for coronary artery disease on chromosome 3q22.3
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New susceptibility locus for coronary artery disease on chromosome 3q22.3. / Erdmann, Jeanette; Grosshennig, Anika; Braund, Peter S; König, Inke R; Hengstenberg, Christian; Hall, Alistair S; Linsel-Nitschke, Patrick; Kathiresan, Sekar; Wright, Ben; Trégouët, David-Alexandre; Cambien, Francois; Bruse, Petra; Aherrahrou, Zouhair; Wagner, Arnika K; Stark, Klaus; Schwartz, Stephen M; Salomaa, Veikko; Elosua, Roberto; Melander, Olle; Voight, Benjamin F; O'Donnell, Christopher J; Peltonen, Leena; Siscovick, David S; Altshuler, David; Merlini, Piera Angelica; Peyvandi, Flora; Bernardinelli, Luisa; Ardissino, Diego; Schillert, Arne; Blankenberg, Stefan; Zeller, Tanja; Wild, Philipp; Schwarz, Daniel F; Tiret, Laurence; Perret, Claire; Schreiber, Stefan; El Mokhtari, Nour Eddine; Schäfer, Arne; März, Winfried; Renner, Wilfried; Bugert, Peter; Klüter, Harald; Schrezenmeir, Jürgen; Rubin, Diana; Ball, Stephen G; Balmforth, Anthony J; Wichmann, H-Erich; Meitinger, Thomas; Fischer, Marcus; Meisinger, Christa; Baumert, Jens; Peters, Annette; Ouwehand, Willem H; Deloukas, Panos; Thompson, John R; Ziegler, Andreas; Samani, Nilesh J; Schunkert, Heribert; Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group.
in: NAT GENET, Jahrgang 41, Nr. 3, 03.2009, S. 280-282.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - New susceptibility locus for coronary artery disease on chromosome 3q22.3
AU - Erdmann, Jeanette
AU - Grosshennig, Anika
AU - Braund, Peter S
AU - König, Inke R
AU - Hengstenberg, Christian
AU - Hall, Alistair S
AU - Linsel-Nitschke, Patrick
AU - Kathiresan, Sekar
AU - Wright, Ben
AU - Trégouët, David-Alexandre
AU - Cambien, Francois
AU - Bruse, Petra
AU - Aherrahrou, Zouhair
AU - Wagner, Arnika K
AU - Stark, Klaus
AU - Schwartz, Stephen M
AU - Salomaa, Veikko
AU - Elosua, Roberto
AU - Melander, Olle
AU - Voight, Benjamin F
AU - O'Donnell, Christopher J
AU - Peltonen, Leena
AU - Siscovick, David S
AU - Altshuler, David
AU - Merlini, Piera Angelica
AU - Peyvandi, Flora
AU - Bernardinelli, Luisa
AU - Ardissino, Diego
AU - Schillert, Arne
AU - Blankenberg, Stefan
AU - Zeller, Tanja
AU - Wild, Philipp
AU - Schwarz, Daniel F
AU - Tiret, Laurence
AU - Perret, Claire
AU - Schreiber, Stefan
AU - El Mokhtari, Nour Eddine
AU - Schäfer, Arne
AU - März, Winfried
AU - Renner, Wilfried
AU - Bugert, Peter
AU - Klüter, Harald
AU - Schrezenmeir, Jürgen
AU - Rubin, Diana
AU - Ball, Stephen G
AU - Balmforth, Anthony J
AU - Wichmann, H-Erich
AU - Meitinger, Thomas
AU - Fischer, Marcus
AU - Meisinger, Christa
AU - Baumert, Jens
AU - Peters, Annette
AU - Ouwehand, Willem H
AU - Deloukas, Panos
AU - Thompson, John R
AU - Ziegler, Andreas
AU - Samani, Nilesh J
AU - Schunkert, Heribert
AU - Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group
PY - 2009/3
Y1 - 2009/3
N2 - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
AB - We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
KW - Case-Control Studies
KW - Chromosomes, Human, Pair 3
KW - Coronary Artery Disease/genetics
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Germany
KW - Hepatocyte Nuclear Factor 1-alpha/genetics
KW - Humans
KW - Polymorphism, Single Nucleotide
KW - Quantitative Trait Loci
KW - ras Proteins/genetics
U2 - 10.1038/ng.307
DO - 10.1038/ng.307
M3 - SCORING: Journal article
C2 - 19198612
VL - 41
SP - 280
EP - 282
JO - NAT GENET
JF - NAT GENET
SN - 1061-4036
IS - 3
ER -