New loci associated with kidney function and chronic kidney disease

Anna Köttgen; Cristian Pattaro; Carsten A Böger; Christian Fuchsberger; Matthias Olden; Nicole L Glazer; Afshin Parsa; Xiaoyi Gao; Qiong Yang; Albert V Smith; Jeffrey R O'Connell; Man Li; Helena Schmidt; Toshiko Tanaka; Aaron Isaacs; Shamika Ketkar; Shih-Jen Hwang; Andrew D Johnson; Abbas Dehghan; Alexander Teumer; Guillaume Paré; Elizabeth J Atkinson; Tanja Zeller; Kurt Lohman; Marilyn C Cornelis; Nicole M Probst-Hensch; Florian Kronenberg; Anke Tönjes; Caroline Hayward; Thor Aspelund; Gudny Eiriksdottir; Lenore J Launer; Tamara B Harris; Evadnie Rampersaud; Braxton D Mitchell; Dan E Arking; Eric Boerwinkle; Maksim Struchalin; Margherita Cavalieri; Andrew Singleton; Francesco Giallauria; Jeffrey Metter; Ian H de Boer; Talin Haritunians; Thomas Lumley; David Siscovick; Bruce M Psaty; M Carola Zillikens; Ben A Oostra; Mary Feitosa; Michael Province; Mariza de Andrade; Stephen T Turner; Arne Schillert; Andreas Ziegler; Philipp S Wild; Renate B Schnabel; Sandra Wilde; Thomas F Munzel; Tennille S Leak; Thomas Illig; Norman Klopp; Christa Meisinger; H-Erich Wichmann; Wolfgang Koenig; Lina Zgaga; Tatijana Zemunik; Ivana Kolcic; Cosetta Minelli; Frank B Hu; Asa Johansson; Wilmar Igl; Ghazal Zaboli; Sarah H Wild; Alan F Wright; Harry Campbell; David Ellinghaus; Stefan Schreiber; Yurii S Aulchenko; Janine F Felix; Fernando Rivadeneira; Andre G Uitterlinden; Albert Hofman; Medea Imboden; Dorothea Nitsch; Anita Brandstätter; Barbara Kollerits; Lyudmyla Kedenko; Reedik Mägi; Michael Stumvoll; Peter Kovacs; Mladen Boban; Susan Campbell; Karlhans Endlich; Henry Völzke; Heyo K Kroemer; Matthias Nauck; Uwe Völker; Ozren Polasek; Veronique Vitart; Sunita Badola; Alexander N Parker; Paul M Ridker; Sharon L R Kardia; Stefan Blankenberg; Yongmei Liu; Gary C Curhan; Andre Franke; Thierry Rochat; Bernhard Paulweber; Inga Prokopenko; Wei Wang; Vilmundur Gudnason; Alan R Shuldiner; Josef Coresh; Reinhold Schmidt; Luigi Ferrucci; Michael G Shlipak; Cornelia M van Duijn; Ingrid Borecki; Bernhard K Krämer; Igor Rudan; Ulf Gyllensten; James F Wilson; Jacqueline C Witteman; Peter P Pramstaller; Rainer Rettig; Nick Hastie; Daniel I Chasman; W H Kao; Iris M Heid; Caroline S Fox

doi:10.1038/ng.568

New loci associated with kidney function and chronic kidney disease

Standard

New loci associated with kidney function and chronic kidney disease. / Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L; Parsa, Afshin; Gao, Xiaoyi; Yang, Qiong; Smith, Albert V; O'Connell, Jeffrey R; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih-Jen; Johnson, Andrew D; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C; Probst-Hensch, Nicole M; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore J; Harris, Tamara B; Rampersaud, Evadnie; Mitchell, Braxton D; Arking, Dan E; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Giallauria, Francesco; Metter, Jeffrey; de Boer, Ian H; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M; Zillikens, M Carola; Oostra, Ben A; Feitosa, Mary; Province, Michael; de Andrade, Mariza; Turner, Stephen T; Schillert, Arne; Ziegler, Andreas; Wild, Philipp S; Schnabel, Renate B; Wilde, Sandra; Munzel, Thomas F; Leak, Tennille S; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H-Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Hu, Frank B; Johansson, Asa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H; Wright, Alan F; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S; Felix, Janine F; Rivadeneira, Fernando; Uitterlinden, Andre G; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N; Ridker, Paul M; Kardia, Sharon L R; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldiner, Alan R; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G; van Duijn, Cornelia M; Borecki, Ingrid; Krämer, Bernhard K; Rudan, Igor; Gyllensten, Ulf; Wilson, James F; Witteman, Jacqueline C; Pramstaller, Peter P; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I; Kao, W H; Heid, Iris M; Fox, Caroline S.

In: NAT GENET, Vol. 42, No. 5, 05.2010, p. 376-384.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Köttgen, A, Pattaro, C, Böger, CA, Fuchsberger, C, Olden, M, Glazer, NL, Parsa, A, Gao, X, Yang, Q, Smith, AV, O'Connell, JR, Li, M, Schmidt, H, Tanaka, T, Isaacs, A, Ketkar, S, Hwang, S-J, Johnson, AD, Dehghan, A, Teumer, A, Paré, G, Atkinson, EJ, Zeller, T, Lohman, K, Cornelis, MC, Probst-Hensch, NM, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, LJ, Harris, TB, Rampersaud, E, Mitchell, BD, Arking, DE, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer, IH, Haritunians, T, Lumley, T, Siscovick, D, Psaty, BM, Zillikens, MC, Oostra, BA, Feitosa, M, Province, M, de Andrade, M, Turner, ST, Schillert, A, Ziegler, A, Wild, PS, Schnabel, RB, Wilde, S, Munzel, TF, Leak, TS, Illig, T, Klopp, N, Meisinger, C, Wichmann, H-E, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, FB, Johansson, A, Igl, W, Zaboli, G, Wild, SH, Wright, AF, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, YS, Felix, JF, Rivadeneira, F, Uitterlinden, AG, Hofman, A, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, HK, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, AN, Ridker, PM, Kardia, SLR, Blankenberg, S, Liu, Y, Curhan, GC, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Gudnason, V, Shuldiner, AR, Coresh, J, Schmidt, R, Ferrucci, L, Shlipak, MG, van Duijn, CM, Borecki, I, Krämer, BK, Rudan, I, Gyllensten, U, Wilson, JF, Witteman, JC, Pramstaller, PP, Rettig, R, Hastie, N, Chasman, DI, Kao, WH, Heid, IM & Fox, CS 2010, 'New loci associated with kidney function and chronic kidney disease', NAT GENET, vol. 42, no. 5, pp. 376-384. https://doi.org/10.1038/ng.568

APA

Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., O'Connell, J. R., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, S-J., Johnson, A. D., Dehghan, A., ... Fox, C. S. (2010). New loci associated with kidney function and chronic kidney disease. NAT GENET, 42(5), 376-384. https://doi.org/10.1038/ng.568

Vancouver

Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL et al. New loci associated with kidney function and chronic kidney disease. NAT GENET. 2010 May;42(5):376-384. https://doi.org/10.1038/ng.568

Bibtex

@article{3829d70b1b0543dab99b1f38c1b7a92f,

title = "New loci associated with kidney function and chronic kidney disease",

abstract = "Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.",

keywords = "Cohort Studies, Creatinine/blood, Cystatin C/genetics, Diet, Europe, Genetic Markers/genetics, Genome-Wide Association Study, Glomerular Filtration Rate, Humans, Kidney/physiology, Kidney Failure, Chronic/ethnology, Models, Genetic, Risk Factors",

author = "Anna K{\"o}ttgen and Cristian Pattaro and B{\"o}ger, {Carsten A} and Christian Fuchsberger and Matthias Olden and Glazer, {Nicole L} and Afshin Parsa and Xiaoyi Gao and Qiong Yang and Smith, {Albert V} and O'Connell, {Jeffrey R} and Man Li and Helena Schmidt and Toshiko Tanaka and Aaron Isaacs and Shamika Ketkar and Shih-Jen Hwang and Johnson, {Andrew D} and Abbas Dehghan and Alexander Teumer and Guillaume Par{\'e} and Atkinson, {Elizabeth J} and Tanja Zeller and Kurt Lohman and Cornelis, {Marilyn C} and Probst-Hensch, {Nicole M} and Florian Kronenberg and Anke T{\"o}njes and Caroline Hayward and Thor Aspelund and Gudny Eiriksdottir and Launer, {Lenore J} and Harris, {Tamara B} and Evadnie Rampersaud and Mitchell, {Braxton D} and Arking, {Dan E} and Eric Boerwinkle and Maksim Struchalin and Margherita Cavalieri and Andrew Singleton and Francesco Giallauria and Jeffrey Metter and {de Boer}, {Ian H} and Talin Haritunians and Thomas Lumley and David Siscovick and Psaty, {Bruce M} and Zillikens, {M Carola} and Oostra, {Ben A} and Mary Feitosa and Michael Province and {de Andrade}, Mariza and Turner, {Stephen T} and Arne Schillert and Andreas Ziegler and Wild, {Philipp S} and Schnabel, {Renate B} and Sandra Wilde and Munzel, {Thomas F} and Leak, {Tennille S} and Thomas Illig and Norman Klopp and Christa Meisinger and H-Erich Wichmann and Wolfgang Koenig and Lina Zgaga and Tatijana Zemunik and Ivana Kolcic and Cosetta Minelli and Hu, {Frank B} and Asa Johansson and Wilmar Igl and Ghazal Zaboli and Wild, {Sarah H} and Wright, {Alan F} and Harry Campbell and David Ellinghaus and Stefan Schreiber and Aulchenko, {Yurii S} and Felix, {Janine F} and Fernando Rivadeneira and Uitterlinden, {Andre G} and Albert Hofman and Medea Imboden and Dorothea Nitsch and Anita Brandst{\"a}tter and Barbara Kollerits and Lyudmyla Kedenko and Reedik M{\"a}gi and Michael Stumvoll and Peter Kovacs and Mladen Boban and Susan Campbell and Karlhans Endlich and Henry V{\"o}lzke and Kroemer, {Heyo K} and Matthias Nauck and Uwe V{\"o}lker and Ozren Polasek and Veronique Vitart and Sunita Badola and Parker, {Alexander N} and Ridker, {Paul M} and Kardia, {Sharon L R} and Stefan Blankenberg and Yongmei Liu and Curhan, {Gary C} and Andre Franke and Thierry Rochat and Bernhard Paulweber and Inga Prokopenko and Wei Wang and Vilmundur Gudnason and Shuldiner, {Alan R} and Josef Coresh and Reinhold Schmidt and Luigi Ferrucci and Shlipak, {Michael G} and {van Duijn}, {Cornelia M} and Ingrid Borecki and Kr{\"a}mer, {Bernhard K} and Igor Rudan and Ulf Gyllensten and Wilson, {James F} and Witteman, {Jacqueline C} and Pramstaller, {Peter P} and Rainer Rettig and Nick Hastie and Chasman, {Daniel I} and Kao, {W H} and Heid, {Iris M} and Fox, {Caroline S}",

year = "2010",

month = may,

doi = "10.1038/ng.568",

language = "English",

volume = "42",

pages = "376--384",

journal = "NAT GENET",

issn = "1061-4036",

publisher = "NATURE PUBLISHING GROUP",

number = "5",

}

RIS

TY - JOUR

T1 - New loci associated with kidney function and chronic kidney disease

AU - Köttgen, Anna

AU - Pattaro, Cristian

AU - Böger, Carsten A

AU - Fuchsberger, Christian

AU - Olden, Matthias

AU - Glazer, Nicole L

AU - Parsa, Afshin

AU - Gao, Xiaoyi

AU - Yang, Qiong

AU - Smith, Albert V

AU - O'Connell, Jeffrey R

AU - Li, Man

AU - Schmidt, Helena

AU - Tanaka, Toshiko

AU - Isaacs, Aaron

AU - Ketkar, Shamika

AU - Hwang, Shih-Jen

AU - Johnson, Andrew D

AU - Dehghan, Abbas

AU - Teumer, Alexander

AU - Paré, Guillaume

AU - Atkinson, Elizabeth J

AU - Zeller, Tanja

AU - Lohman, Kurt

AU - Cornelis, Marilyn C

AU - Probst-Hensch, Nicole M

AU - Kronenberg, Florian

AU - Tönjes, Anke

AU - Hayward, Caroline

AU - Aspelund, Thor

AU - Eiriksdottir, Gudny

AU - Launer, Lenore J

AU - Harris, Tamara B

AU - Rampersaud, Evadnie

AU - Mitchell, Braxton D

AU - Arking, Dan E

AU - Boerwinkle, Eric

AU - Struchalin, Maksim

AU - Cavalieri, Margherita

AU - Singleton, Andrew

AU - Giallauria, Francesco

AU - Metter, Jeffrey

AU - de Boer, Ian H

AU - Haritunians, Talin

AU - Lumley, Thomas

AU - Siscovick, David

AU - Psaty, Bruce M

AU - Zillikens, M Carola

AU - Oostra, Ben A

AU - Feitosa, Mary

AU - Province, Michael

AU - de Andrade, Mariza

AU - Turner, Stephen T

AU - Schillert, Arne

AU - Ziegler, Andreas

AU - Wild, Philipp S

AU - Schnabel, Renate B

AU - Wilde, Sandra

AU - Munzel, Thomas F

AU - Leak, Tennille S

AU - Illig, Thomas

AU - Klopp, Norman

AU - Meisinger, Christa

AU - Wichmann, H-Erich

AU - Koenig, Wolfgang

AU - Zgaga, Lina

AU - Zemunik, Tatijana

AU - Kolcic, Ivana

AU - Minelli, Cosetta

AU - Hu, Frank B

AU - Johansson, Asa

AU - Igl, Wilmar

AU - Zaboli, Ghazal

AU - Wild, Sarah H

AU - Wright, Alan F

AU - Campbell, Harry

AU - Ellinghaus, David

AU - Schreiber, Stefan

AU - Aulchenko, Yurii S

AU - Felix, Janine F

AU - Rivadeneira, Fernando

AU - Uitterlinden, Andre G

AU - Hofman, Albert

AU - Imboden, Medea

AU - Nitsch, Dorothea

AU - Brandstätter, Anita

AU - Kollerits, Barbara

AU - Kedenko, Lyudmyla

AU - Mägi, Reedik

AU - Stumvoll, Michael

AU - Kovacs, Peter

AU - Boban, Mladen

AU - Campbell, Susan

AU - Endlich, Karlhans

AU - Völzke, Henry

AU - Kroemer, Heyo K

AU - Nauck, Matthias

AU - Völker, Uwe

AU - Polasek, Ozren

AU - Vitart, Veronique

AU - Badola, Sunita

AU - Parker, Alexander N

AU - Ridker, Paul M

AU - Kardia, Sharon L R

AU - Blankenberg, Stefan

AU - Liu, Yongmei

AU - Curhan, Gary C

AU - Franke, Andre

AU - Rochat, Thierry

AU - Paulweber, Bernhard

AU - Prokopenko, Inga

AU - Wang, Wei

AU - Gudnason, Vilmundur

AU - Shuldiner, Alan R

AU - Coresh, Josef

AU - Schmidt, Reinhold

AU - Ferrucci, Luigi

AU - Shlipak, Michael G

AU - van Duijn, Cornelia M

AU - Borecki, Ingrid

AU - Krämer, Bernhard K

AU - Rudan, Igor

AU - Gyllensten, Ulf

AU - Wilson, James F

AU - Witteman, Jacqueline C

AU - Pramstaller, Peter P

AU - Rettig, Rainer

AU - Hastie, Nick

AU - Chasman, Daniel I

AU - Kao, W H

AU - Heid, Iris M

AU - Fox, Caroline S

PY - 2010/5

Y1 - 2010/5

N2 - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

AB - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

KW - Cohort Studies

KW - Creatinine/blood

KW - Cystatin C/genetics

KW - Diet

KW - Europe

KW - Genetic Markers/genetics

KW - Genome-Wide Association Study

KW - Glomerular Filtration Rate

KW - Humans

KW - Kidney/physiology

KW - Kidney Failure, Chronic/ethnology

KW - Models, Genetic

KW - Risk Factors

U2 - 10.1038/ng.568

DO - 10.1038/ng.568

M3 - SCORING: Journal article

C2 - 20383146

VL - 42

SP - 376

EP - 384

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 5

ER -