New loci associated with kidney function and chronic kidney disease
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New loci associated with kidney function and chronic kidney disease. / Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L; Parsa, Afshin; Gao, Xiaoyi; Yang, Qiong; Smith, Albert V; O'Connell, Jeffrey R; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih-Jen; Johnson, Andrew D; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C; Probst-Hensch, Nicole M; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore J; Harris, Tamara B; Rampersaud, Evadnie; Mitchell, Braxton D; Arking, Dan E; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Giallauria, Francesco; Metter, Jeffrey; de Boer, Ian H; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M; Zillikens, M Carola; Oostra, Ben A; Feitosa, Mary; Province, Michael; de Andrade, Mariza; Turner, Stephen T; Schillert, Arne; Ziegler, Andreas; Wild, Philipp S; Schnabel, Renate B; Wilde, Sandra; Munzel, Thomas F; Leak, Tennille S; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H-Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Hu, Frank B; Johansson, Asa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H; Wright, Alan F; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S; Felix, Janine F; Rivadeneira, Fernando; Uitterlinden, Andre G; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N; Ridker, Paul M; Kardia, Sharon L R; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldiner, Alan R; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G; van Duijn, Cornelia M; Borecki, Ingrid; Krämer, Bernhard K; Rudan, Igor; Gyllensten, Ulf; Wilson, James F; Witteman, Jacqueline C; Pramstaller, Peter P; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I; Kao, W H; Heid, Iris M; Fox, Caroline S.
in: NAT GENET, Jahrgang 42, Nr. 5, 05.2010, S. 376-384.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - New loci associated with kidney function and chronic kidney disease
AU - Köttgen, Anna
AU - Pattaro, Cristian
AU - Böger, Carsten A
AU - Fuchsberger, Christian
AU - Olden, Matthias
AU - Glazer, Nicole L
AU - Parsa, Afshin
AU - Gao, Xiaoyi
AU - Yang, Qiong
AU - Smith, Albert V
AU - O'Connell, Jeffrey R
AU - Li, Man
AU - Schmidt, Helena
AU - Tanaka, Toshiko
AU - Isaacs, Aaron
AU - Ketkar, Shamika
AU - Hwang, Shih-Jen
AU - Johnson, Andrew D
AU - Dehghan, Abbas
AU - Teumer, Alexander
AU - Paré, Guillaume
AU - Atkinson, Elizabeth J
AU - Zeller, Tanja
AU - Lohman, Kurt
AU - Cornelis, Marilyn C
AU - Probst-Hensch, Nicole M
AU - Kronenberg, Florian
AU - Tönjes, Anke
AU - Hayward, Caroline
AU - Aspelund, Thor
AU - Eiriksdottir, Gudny
AU - Launer, Lenore J
AU - Harris, Tamara B
AU - Rampersaud, Evadnie
AU - Mitchell, Braxton D
AU - Arking, Dan E
AU - Boerwinkle, Eric
AU - Struchalin, Maksim
AU - Cavalieri, Margherita
AU - Singleton, Andrew
AU - Giallauria, Francesco
AU - Metter, Jeffrey
AU - de Boer, Ian H
AU - Haritunians, Talin
AU - Lumley, Thomas
AU - Siscovick, David
AU - Psaty, Bruce M
AU - Zillikens, M Carola
AU - Oostra, Ben A
AU - Feitosa, Mary
AU - Province, Michael
AU - de Andrade, Mariza
AU - Turner, Stephen T
AU - Schillert, Arne
AU - Ziegler, Andreas
AU - Wild, Philipp S
AU - Schnabel, Renate B
AU - Wilde, Sandra
AU - Munzel, Thomas F
AU - Leak, Tennille S
AU - Illig, Thomas
AU - Klopp, Norman
AU - Meisinger, Christa
AU - Wichmann, H-Erich
AU - Koenig, Wolfgang
AU - Zgaga, Lina
AU - Zemunik, Tatijana
AU - Kolcic, Ivana
AU - Minelli, Cosetta
AU - Hu, Frank B
AU - Johansson, Asa
AU - Igl, Wilmar
AU - Zaboli, Ghazal
AU - Wild, Sarah H
AU - Wright, Alan F
AU - Campbell, Harry
AU - Ellinghaus, David
AU - Schreiber, Stefan
AU - Aulchenko, Yurii S
AU - Felix, Janine F
AU - Rivadeneira, Fernando
AU - Uitterlinden, Andre G
AU - Hofman, Albert
AU - Imboden, Medea
AU - Nitsch, Dorothea
AU - Brandstätter, Anita
AU - Kollerits, Barbara
AU - Kedenko, Lyudmyla
AU - Mägi, Reedik
AU - Stumvoll, Michael
AU - Kovacs, Peter
AU - Boban, Mladen
AU - Campbell, Susan
AU - Endlich, Karlhans
AU - Völzke, Henry
AU - Kroemer, Heyo K
AU - Nauck, Matthias
AU - Völker, Uwe
AU - Polasek, Ozren
AU - Vitart, Veronique
AU - Badola, Sunita
AU - Parker, Alexander N
AU - Ridker, Paul M
AU - Kardia, Sharon L R
AU - Blankenberg, Stefan
AU - Liu, Yongmei
AU - Curhan, Gary C
AU - Franke, Andre
AU - Rochat, Thierry
AU - Paulweber, Bernhard
AU - Prokopenko, Inga
AU - Wang, Wei
AU - Gudnason, Vilmundur
AU - Shuldiner, Alan R
AU - Coresh, Josef
AU - Schmidt, Reinhold
AU - Ferrucci, Luigi
AU - Shlipak, Michael G
AU - van Duijn, Cornelia M
AU - Borecki, Ingrid
AU - Krämer, Bernhard K
AU - Rudan, Igor
AU - Gyllensten, Ulf
AU - Wilson, James F
AU - Witteman, Jacqueline C
AU - Pramstaller, Peter P
AU - Rettig, Rainer
AU - Hastie, Nick
AU - Chasman, Daniel I
AU - Kao, W H
AU - Heid, Iris M
AU - Fox, Caroline S
PY - 2010/5
Y1 - 2010/5
N2 - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
AB - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
KW - Cohort Studies
KW - Creatinine/blood
KW - Cystatin C/genetics
KW - Diet
KW - Europe
KW - Genetic Markers/genetics
KW - Genome-Wide Association Study
KW - Glomerular Filtration Rate
KW - Humans
KW - Kidney/physiology
KW - Kidney Failure, Chronic/ethnology
KW - Models, Genetic
KW - Risk Factors
U2 - 10.1038/ng.568
DO - 10.1038/ng.568
M3 - SCORING: Journal article
C2 - 20383146
VL - 42
SP - 376
EP - 384
JO - NAT GENET
JF - NAT GENET
SN - 1061-4036
IS - 5
ER -