New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E
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New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E. / Sebode, Marcial; Pischke, Sven; Lütgehetmann, Marc; Polywka, Susanne; Quaas, Alexander; Lohse, Ansgar W; Wege, Henning.
In: BMC GASTROENTEROL, Vol. 14, No. 191, 01.01.2014.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E
AU - Sebode, Marcial
AU - Pischke, Sven
AU - Lütgehetmann, Marc
AU - Polywka, Susanne
AU - Quaas, Alexander
AU - Lohse, Ansgar W
AU - Wege, Henning
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND: Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepatitis E that resolved under steroid treatment. To our knowledge, this is the first case report describing supportive steroid monotherapy for acute liver injury due to hepatitis E.CASE PRESENTATION: A 63-year-old Caucasian male presented with acute liver injury of unknown origin. After excluding the most prevalent causes of acute liver injury, liver histology revealed signs of immune-mediated toxic or drug-induced liver injury. Therefore, immunosuppressive treatment with prednisolone was started. After initialization of steroid treatment, polymerase chain reaction analyses of peripheral blood and liver tissue revealed an acute hepatitis E virus infection (genotype 3). Under sustained steroid treatment, acute liver injury improved and hepatitis E infection resolved.CONCLUSION: Steroid treatment might be an option to prevent progress of life-threatening liver failure and liver transplantation in patients with hepatitis E-induced acute liver injury and high-grade inflammation.
AB - BACKGROUND: Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepatitis E that resolved under steroid treatment. To our knowledge, this is the first case report describing supportive steroid monotherapy for acute liver injury due to hepatitis E.CASE PRESENTATION: A 63-year-old Caucasian male presented with acute liver injury of unknown origin. After excluding the most prevalent causes of acute liver injury, liver histology revealed signs of immune-mediated toxic or drug-induced liver injury. Therefore, immunosuppressive treatment with prednisolone was started. After initialization of steroid treatment, polymerase chain reaction analyses of peripheral blood and liver tissue revealed an acute hepatitis E virus infection (genotype 3). Under sustained steroid treatment, acute liver injury improved and hepatitis E infection resolved.CONCLUSION: Steroid treatment might be an option to prevent progress of life-threatening liver failure and liver transplantation in patients with hepatitis E-induced acute liver injury and high-grade inflammation.
U2 - 10.1186/s12876-014-0191-0
DO - 10.1186/s12876-014-0191-0
M3 - SCORING: Journal article
C2 - 25398314
VL - 14
JO - BMC GASTROENTEROL
JF - BMC GASTROENTEROL
SN - 1471-230X
IS - 191
ER -