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New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E

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New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E. / Sebode, Marcial; Pischke, Sven; Lütgehetmann, Marc; Polywka, Susanne; Quaas, Alexander; Lohse, Ansgar W; Wege, Henning.

in: BMC GASTROENTEROL, Jahrgang 14, Nr. 191, 01.01.2014.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sebode, M, Pischke, S, Lütgehetmann, M, Polywka, S, Quaas, A, Lohse, AW & Wege, H 2014, 'New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E', BMC GASTROENTEROL, Jg. 14, Nr. 191. https://doi.org/10.1186/s12876-014-0191-0

APA

Sebode, M., Pischke, S., Lütgehetmann, M., Polywka, S., Quaas, A., Lohse, A. W., & Wege, H. (2014). New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E. BMC GASTROENTEROL, 14(191). https://doi.org/10.1186/s12876-014-0191-0

Vancouver

Sebode M, Pischke S, Lütgehetmann M, Polywka S, Quaas A, Lohse AW et al. New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E. BMC GASTROENTEROL. 2014 Jan 1;14(191). https://doi.org/10.1186/s12876-014-0191-0

Bibtex

@article{6eb08f26cfa14389b3f715639e414461,
title = "New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E",
abstract = "BACKGROUND: Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepatitis E that resolved under steroid treatment. To our knowledge, this is the first case report describing supportive steroid monotherapy for acute liver injury due to hepatitis E.CASE PRESENTATION: A 63-year-old Caucasian male presented with acute liver injury of unknown origin. After excluding the most prevalent causes of acute liver injury, liver histology revealed signs of immune-mediated toxic or drug-induced liver injury. Therefore, immunosuppressive treatment with prednisolone was started. After initialization of steroid treatment, polymerase chain reaction analyses of peripheral blood and liver tissue revealed an acute hepatitis E virus infection (genotype 3). Under sustained steroid treatment, acute liver injury improved and hepatitis E infection resolved.CONCLUSION: Steroid treatment might be an option to prevent progress of life-threatening liver failure and liver transplantation in patients with hepatitis E-induced acute liver injury and high-grade inflammation.",
author = "Marcial Sebode and Sven Pischke and Marc L{\"u}tgehetmann and Susanne Polywka and Alexander Quaas and Lohse, {Ansgar W} and Henning Wege",
year = "2014",
month = jan,
day = "1",
doi = "10.1186/s12876-014-0191-0",
language = "English",
volume = "14",
journal = "BMC GASTROENTEROL",
issn = "1471-230X",
publisher = "BioMed Central Ltd.",
number = "191",

}

RIS

TY - JOUR

T1 - New foe treated with old guns - supportive role of steroids in the treatment of acute severe hepatitis E

AU - Sebode, Marcial

AU - Pischke, Sven

AU - Lütgehetmann, Marc

AU - Polywka, Susanne

AU - Quaas, Alexander

AU - Lohse, Ansgar W

AU - Wege, Henning

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BACKGROUND: Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepatitis E that resolved under steroid treatment. To our knowledge, this is the first case report describing supportive steroid monotherapy for acute liver injury due to hepatitis E.CASE PRESENTATION: A 63-year-old Caucasian male presented with acute liver injury of unknown origin. After excluding the most prevalent causes of acute liver injury, liver histology revealed signs of immune-mediated toxic or drug-induced liver injury. Therefore, immunosuppressive treatment with prednisolone was started. After initialization of steroid treatment, polymerase chain reaction analyses of peripheral blood and liver tissue revealed an acute hepatitis E virus infection (genotype 3). Under sustained steroid treatment, acute liver injury improved and hepatitis E infection resolved.CONCLUSION: Steroid treatment might be an option to prevent progress of life-threatening liver failure and liver transplantation in patients with hepatitis E-induced acute liver injury and high-grade inflammation.

AB - BACKGROUND: Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. However, in individual cases, hepatitis E may lead to life-threatening acute liver failure. In this report, we describe a case of acute liver injury caused by an autochthonous hepatitis E that resolved under steroid treatment. To our knowledge, this is the first case report describing supportive steroid monotherapy for acute liver injury due to hepatitis E.CASE PRESENTATION: A 63-year-old Caucasian male presented with acute liver injury of unknown origin. After excluding the most prevalent causes of acute liver injury, liver histology revealed signs of immune-mediated toxic or drug-induced liver injury. Therefore, immunosuppressive treatment with prednisolone was started. After initialization of steroid treatment, polymerase chain reaction analyses of peripheral blood and liver tissue revealed an acute hepatitis E virus infection (genotype 3). Under sustained steroid treatment, acute liver injury improved and hepatitis E infection resolved.CONCLUSION: Steroid treatment might be an option to prevent progress of life-threatening liver failure and liver transplantation in patients with hepatitis E-induced acute liver injury and high-grade inflammation.

U2 - 10.1186/s12876-014-0191-0

DO - 10.1186/s12876-014-0191-0

M3 - SCORING: Journal article

C2 - 25398314

VL - 14

JO - BMC GASTROENTEROL

JF - BMC GASTROENTEROL

SN - 1471-230X

IS - 191

ER -