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Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation

Standard

Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. / Lindholm, D; Castrén, E; Tsoulfas, P; Kolbeck, R; Berzaghi, M da P; Leingärtner, A; Heisenberg, C P; Tessarollo, L; Parada, L F; Thoenen, H; Tesarollo, L.

In: J CELL BIOL, Vol. 122, No. 2, 01.07.1993, p. 443-50.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lindholm, D, Castrén, E, Tsoulfas, P, Kolbeck, R, Berzaghi, MDP, Leingärtner, A, Heisenberg, CP, Tessarollo, L, Parada, LF, Thoenen, H & Tesarollo, L 1993, 'Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation', J CELL BIOL, vol. 122, no. 2, pp. 443-50.

APA

Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M. D. P., Leingärtner, A., Heisenberg, C. P., Tessarollo, L., Parada, L. F., Thoenen, H., & Tesarollo, L. (1993). Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. J CELL BIOL, 122(2), 443-50.

Vancouver

Lindholm D, Castrén E, Tsoulfas P, Kolbeck R, Berzaghi MDP, Leingärtner A et al. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. J CELL BIOL. 1993 Jul 1;122(2):443-50.

Bibtex

@article{e79f39e90df644ea89f255a90a0a364c,
title = "Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation",
abstract = "Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3), in developing rat cerebellar granule cells both in cell culture and in vivo. In situ hybridization experiments showed that developing Purkinje cells do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study demonstrates a novel interaction between cerebellar granule neurons and developing Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje cell differentiation.",
keywords = "Animals, Cell Differentiation, Cells, Cultured, Cerebellum, Hypothyroidism, In Situ Hybridization, Membrane Glycoproteins, Nerve Growth Factors, Neurons, Neurotrophin 3, Purkinje Cells, RNA, Messenger, Rats, Receptor, trkC, Triiodothyronine",
author = "D Lindholm and E Castr{\'e}n and P Tsoulfas and R Kolbeck and Berzaghi, {M da P} and A Leing{\"a}rtner and Heisenberg, {C P} and L Tessarollo and Parada, {L F} and H Thoenen and L Tesarollo",
year = "1993",
month = jul,
day = "1",
language = "English",
volume = "122",
pages = "443--50",
journal = "J CELL BIOL",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation

AU - Lindholm, D

AU - Castrén, E

AU - Tsoulfas, P

AU - Kolbeck, R

AU - Berzaghi, M da P

AU - Leingärtner, A

AU - Heisenberg, C P

AU - Tessarollo, L

AU - Parada, L F

AU - Thoenen, H

AU - Tesarollo, L

PY - 1993/7/1

Y1 - 1993/7/1

N2 - Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3), in developing rat cerebellar granule cells both in cell culture and in vivo. In situ hybridization experiments showed that developing Purkinje cells do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study demonstrates a novel interaction between cerebellar granule neurons and developing Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje cell differentiation.

AB - Thyroid hormones play an important role in brain development, but the mechanism(s) by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood. Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3 (NT-3), in developing rat cerebellar granule cells both in cell culture and in vivo. In situ hybridization experiments showed that developing Purkinje cells do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study demonstrates a novel interaction between cerebellar granule neurons and developing Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje cell differentiation.

KW - Animals

KW - Cell Differentiation

KW - Cells, Cultured

KW - Cerebellum

KW - Hypothyroidism

KW - In Situ Hybridization

KW - Membrane Glycoproteins

KW - Nerve Growth Factors

KW - Neurons

KW - Neurotrophin 3

KW - Purkinje Cells

KW - RNA, Messenger

KW - Rats

KW - Receptor, trkC

KW - Triiodothyronine

M3 - SCORING: Journal article

C2 - 8320266

VL - 122

SP - 443

EP - 450

JO - J CELL BIOL

JF - J CELL BIOL

SN - 0021-9525

IS - 2

ER -